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Multilevel Monte Carlo estimation of expected information gains

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TLDR
An efficient algorithm to estimate the expected information gain by applying a multilevel Monte Carlo (MLMC) method is developed and an antithetic MLMC estimator is introduced to provide a sufficient condition on the data model under which the antithetic property of the MLMC estimation is well exploited such that optimal complexity of is achieved.
Abstract
The expected information gain is an important quality criterion of Bayesian experimental designs, which measures how much the information entropy about uncertain quantity of interest $\theta$ is reduced on average by collecting relevant data $Y$. However, estimating the expected information gain has been considered computationally challenging since it is defined as a nested expectation with an outer expectation with respect to $Y$ and an inner expectation with respect to $\theta$. In fact, the standard, nested Monte Carlo method requires a total computational cost of $O(\varepsilon^{-3})$ to achieve a root-mean-square accuracy of $\varepsilon$. In this paper we develop an efficient algorithm to estimate the expected information gain by applying a multilevel Monte Carlo (MLMC) method. To be precise, we introduce an antithetic MLMC estimator for the expected information gain and provide a sufficient condition on the data model under which the antithetic property of the MLMC estimator is well exploited such that optimal complexity of $O(\varepsilon^{-2})$ is achieved. Furthermore, we discuss how to incorporate importance sampling techniques within the MLMC estimator to avoid arithmetic underflow. Numerical experiments show the considerable computational cost savings compared to the nested Monte Carlo method for a simple test case and a more realistic pharmacokinetic model.

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Citations
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Journal ArticleDOI

Multilevel Monte Carlo Estimation of the Expected Value of Sample Information

TL;DR: It is shown, under a set of assumptions on decision and information models, that successive approximation levels are tightly coupled, which directly proves that the proposed MLMC estimator improves the necessary computational cost to optimal $O(\varepsilon^{-2})$.
Journal ArticleDOI

Optimal Bayesian experimental design for subsurface flow problems

TL;DR: A novel approach for development of polynomial chaos expansion surrogate model for the design utility function by demonstrating how the orthogonality of PCE basis polynomials can be utilized in order to replace the expensive integration over the space of possible observations by direct construction ofPCE approximation for the expected information gain.
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Unbiased MLMC stochastic gradient-based optimization of Bayesian experimental designs.

TL;DR: An unbiased Monte Carlo estimator is introduced for the gradient of the expected information gain with finite expected squared $\ell_2$-norm and finite expected computational cost per sample.
Proceedings Article

Optimizing Sequential Experimental Design with Deep Reinforcement Learning

TL;DR: The problem of optimizing policies can be reduced to solving a Markov decision process (MDP) with modern deep reinforcement learning techniques and exhibits state-of-the-art performance on both continuous and discrete design spaces, even when the probabilistic model is a black box.
Posted Content

Multilevel Double Loop Monte Carlo and Stochastic Collocation Methods with Importance Sampling for Bayesian Optimal Experimental Design

TL;DR: Two multilevel methods for estimating a popular criterion known as the expected information gain (EIG) in Bayesian optimal experimental design are proposed, which are a multilesvel strategy with double loop Monte Carlo and a multileVEL double loop stochastic collocation, which performs a high‐dimensional integration on sparse grids.
References
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Journal ArticleDOI

Bayesian Experimental Design: A Review

TL;DR: This paper reviews the literature on Bayesian experimental design, both for linear and nonlinear models, and presents a uniied view of the topic by putting experimental design in a decision theoretic framework.
Journal ArticleDOI

Multilevel Monte Carlo Path Simulation

TL;DR: It is shown that multigrid ideas can be used to reduce the computational complexity of estimating an expected value arising from a stochastic differential equation using Monte Carlo path simulations.
Journal ArticleDOI

On a Measure of the Information Provided by an Experiment

TL;DR: In this paper, a measure of the information provided by an experiment is introduced, derived from the work of Shannon and involves the knowledge prior to performing the experiment, expressed through a prior probability distribution over the parameter space.
Journal ArticleDOI

Multilevel Monte Carlo methods

TL;DR: A review of the progress in multilevel Monte Carlo path simulation can be found in this article, where the authors highlight the simplicity, flexibility and generality of the multi-level Monte Carlo approach.
Journal ArticleDOI

Simulation-based optimal Bayesian experimental design for nonlinear systems

TL;DR: This work proposes a general mathematical framework and an algorithmic approach for optimal experimental design with nonlinear simulation-based models, and focuses on finding sets of experiments that provide the most information about targeted sets of parameters.
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