Journal ArticleDOI
Multiple monoamine oxidases in rat liver mitochondria
L. Sierens,A. D'Iorio +1 more
TLDR
Indirect evidence from the kinetics of oxidative deamination is presented for the existence of two different monoamine oxidases in rat liver mitochondria, each with the characteristics predicted from the kinetic experiments.Abstract:
Indirect evidence from the kinetics of oxidative deamination is presented for the existence of two different monoamine oxidases in rat liver mitochondria. The enzymes can be differentiated on the basis of their affinities for benzylamine and serotonin. Electrophoretic separation yielded two fractions, each with the characteristics predicted from the kinetic experiments.read more
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Journal ArticleDOI
Evidence for a specific monoamine oxidase associated with sympathetic nerves.
C. Goridis,Norton H. Neff +1 more
TL;DR: Rat brain has been found to contain two forms of monoamine oxidase: an enzyme highly sensitive to the inhibitor clorgyline that acted on tyramine and serotonin (Type A).
Journal ArticleDOI
Monoamine oxidase in sympathetic nerves: a transmitter specific enzyme type.
C. Goridis,Norton H. Neff +1 more
TL;DR: The observations are consistent with the hypothesis that a specific intraneuronal monoamine oxidase plays an important role in the catabolism of noradrenaline in sympathetic nerves and conclude that tyramine is deaminated by both A and B enzymes whereas norad Renaline isDeaminated only by enzyme A, the enzyme which is most active in the ganglion.
Journal ArticleDOI
Monoamine oxidase in rat arteries: evidence for different forms and selective localization.
TL;DR: In this article, two forms of monoamine oxidase activity were differentiated in rat mesenteric and femoral artery by means of substrate and inhibitor specificities: one form deaminated tyramine, 5-hydroxytryptamine and noradrenaline and was highly sensitive to pargyline and clorgyline but resistant towards carbonyl reagents.
Journal ArticleDOI
Effects of tricyclic antidepressants upon human platelet monoamine oxidase.
TL;DR: The findings suggest that selective inhibition of phenylethylamine oxidation may mediate the antidepressant actions of tricyclics and provide some evidence for the existence of multiple catalytic sites of MAO activity in the human platelet.