Open AccessJournal Article
Mutagenic Effects of Potassium Dichromate as Evaluated by Means of Animal and Plant Bioindicators.
Carlos Rocha,Plínio Cerqueira dos Santos Cardoso,Lorena Araújo da Cunha,Cláudia Gomes,Rubens Ribeiro Júnior,Raul Henrique Pinheiro,Mary Helen Pestana da Costa,Rommel Rodríguez Burbano +7 more
TLDR
The findings indicate that at the concentration tested, the chromium compound is a clastogenic as well as an aneugenic in animal and plant bioindicators.Abstract:
Background Chromium typically occurs in two oxidation states in the natural environment, Cr(3+) [Cr(III)] and Cr(6+) [Cr(VI)]. Out of the two chromium species, Cr(VI) is the most mobile, labile and toxic. Hexavalent chromium [Cr(VI)] compounds are classified by the International Agency for Research on Cancer (IARC) as carcinogenic agents to humans. The main source of release of chromium in aquatic ecosystems is related to the industrial application of this metal in metallurgies, tanneries, and in the manufacturing of paints and dyes. The ecotoxicology of Cr(VI) is linked to its environmental persistence and the ability to induce adverse effects in biological systems. In the present study, we evaluated mutagenic effects of Cr(VI) in animal and plant bioindicators. Materials and methods We evaluated primary DNA damage and frequencies of micronuclei (MN) and morphological nuclear abnormalities (NA) in erythrocytes in peripheral blood of the fish Oreochromis niloticus exposed to potassium dichromate at 12 mg l(-1). The genotoxicity and cytotoxicity of Cr(VI) in the onion (Allium cepa) test were also assessed. Results The comet assay showed a significant increase of tailed nucleoids in the erythrocytes of fish treated with K2Cr2O7; MN frequency was also increased in the treatments; cytotoxicity of a low concentration of potassium dichromate, however, was not confirmed. Conclusion The combination of both systems - animal and plant - is adequate and advantageous for mutagenicity evaluation. The findings indicate that at the concentration tested, the chromium compound is a clastogenic as well as an aneugenic.read more
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Bone marrow mesenchymal stem cells repair Cr (VI)- injured kidney by regulating mitochondria-mediated apoptosis and mitophagy mediated via the MAPK signaling pathway
TL;DR: The results suggested that BMSCs repaired Cr (VI)-injured kidney through decreasing mitochondria-mediated apoptosis and mitophagy mediated by downregulating phosphorylation of p38 and JNK, upregulating chromium content of ERK.
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Mutagenic and histopathological effects of hexavalent chromium in tadpoles of Lithobates catesbeianus (Shaw, 1802) (Anura, Ranidae).
José Augusto do Nascimento Monteiro,Lorena Araújo da Cunha,Mary Helen Pestana da Costa,Herald Souza dos Reis,Aliceane Carolina da Silva Aguiar,Veronica Regina Lobato de Oliveira-Bahia,Rommel Rodríguez Burbano,Carlos Alberto Machado da Rocha +7 more
TL;DR: Hexavalent chromium was mutagenic to L. catesbeianus tadpoles and its toxic effects also resulted in anti-mitotic activity, besides inducing histopathological alterations in liver and kidney.
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Metal bioaccumulation and mutagenesis in a Tradescantia clone following long-term exposure to soils from urban industrial areas and closed landfills
Tatjana Čėsnienė,Violeta Kleizaitė,Skaistė Bondzinskaitė,Ričardas Taraškevičius,Donatas Žvingila,Raimondas Šiukšta,Vytautas Rančelis +6 more
TL;DR: Metal accumulation levels in plants and soils showed significant differences, providing a better understanding of the genotoxicity of soils from closed landfills and highlighting the need to determine the concentrations of metals and other genotoxicants in plants in relation to genot toxicity.
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DNA methylation modifications induced by hexavalent chromium
TL;DR: The aim of this review is to summarize the understanding regarding the effects of Cr (VI) on global and gene-specific DNA methylation.
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Distribution of Cr and Pb in artificial sea water and their sorption in marine sediments: an example from experimental mesocosms.
Antonella Maccotta,Claudia Cosentino,Rodolfo Coccioni,Fabrizio Frontalini,Giovanna Scopelliti,Antonio Caruso +5 more
TL;DR: The uptake of two heavy metals (chromium and lead) in sediments in experimental mesocosms under exposure to different metal concentrations was evaluated by monitoring their concentrations over time both in seawater and in sediment.