Journal ArticleDOI
Mutagenicity tests with nickel salts in the male mouse
Gh. Deknudt,A. Leonard +1 more
TLDR
It is concluded that nickel probably has no clastogenic properties in mammals and does not increase the rate of post-implantation death.About:
This article is published in Toxicology.The article was published on 1982-01-01. It has received 20 citations till now. The article focuses on the topics: Micronucleus test.read more
Citations
More filters
Journal ArticleDOI
Cyclophosphamide: Review of its mutagenicity for an assessment of potential germ cell risks
TL;DR: There is a maximum dose and an optimum time for the detection of genetic effects because the toxicity associated with high doses of CP will affect cell division and increases in chromosome damage and gene mutations have been found in the peripheral blood lymphocytes of nurses, pharmacists and female workers occupationally exposured to CP.
Journal ArticleDOI
A core in vitro genotoxicity battery comprising the Ames test plus the in vitro micronucleus test is sufficient to detect rodent carcinogens and in vivo genotoxins.
TL;DR: There is no convincing evidence that any genotoxic rodent carcinogens or in vivo genotoxins would remain undetected in an in vitro test battery consisting of Ames+MNvit.
Journal ArticleDOI
EFSA CONTAM Panel (EFSA Panel on Contaminants in the Food Chain), 2015. Scientific Opinion on the risks to public health related to the presence of nickel in food and drinking water
TL;DR: Overall, the CONTAM Panel concluded that, at the current levels of acute dietary exposure to Ni, there is a concern that Nisensitized individuals may develop eczematous flare-up skin reactions.
Journal ArticleDOI
Bone marrow micronucleus assay: a review of the mouse stocks used and their published mean spontaneous micronucleus frequencies.
TL;DR: This analysis bears out the recommendation of the first Gene‐Tox Report on the micronucleus assay that the historical negative control frequency for a mouse stock should fall between 1 and 3 mnPCE/1,000 and suggests that the recommended range for historical mean frequency should be extended slightly.
References
More filters
Book ChapterDOI
The Micronucleus Test for Cytogenetic Analysis
TL;DR: Micronuclei originate from chromatin which for different reasons has been lagging in anaphase, and in the course of telophase this material is included into one or the other daughter cell where it either can fuse with the main nucleus or form one or several secondary nuclei.
Book ChapterDOI
Dominant Lethal Mutations in Mammals
TL;DR: The dominant lethal assay in mice, as described in this chapter, meets both speed and simplicity and relevance to problems of human exposure.
Journal ArticleDOI
Chromosome damage in human cell cultures induced by metal salts
Gillian R. Paton,A. C. Allison +1 more
Journal ArticleDOI
Inducibility of chromosomal aberrations by metal compounds in cultured mammalian cells.
TL;DR: The rate of chromosomal aberrations induced by metal compounds increased with an increase in treatment time from 24 to 48 h, indicating a time-dependent increase in the hereditable toxicity of metal compounds.
Journal ArticleDOI
Carcinogenicity, mutagenicity and teratogenicity of nickel.
TL;DR: E Epidemiological investigations and experimental studies have demonstrated that certain nickel compounds are extremely potent carcinogens after inhalation, but also that the carcinogenic risk is limited to conditions of occupational exposure.
Related Papers (5)
Modifying role of Phyllanthus emblica and ascorbic acid against nickel clastogenicity in mice.
Assessment of the uptake and mutagenicity of nickel chloride in salmonella tester strains.
The induction of DNA strand breakage by nickel compounds in cultured Chinese hamster ovary cells
Steven H. Robison,Max Costa +1 more