Journal ArticleDOI
Assessment of the uptake and mutagenicity of nickel chloride in salmonella tester strains.
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TLDR
Results suggest that nickel is unable to induce basepair or frameshift mutations in Salmonella tester strains and are discussed in relationship to the low binding affinity of Ni(II) for DNA.Abstract:
NiCl2 was examined for mutagenic activity in a number of Salmonella tester strains. Conditions were established where there was substantial uptake of the metal into the bacterial cells. However, even when the metal ion was apparently taken up, as determined by metal association with cells, there was a lack of mutagenic activity. These results suggest that nickel is unable to induce basepair or frameshift mutations in Salmonella tester strains and are discussed in relationship to the low binding affinity of Ni(II) for DNA.read more
Citations
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Nickel essentiality, toxicity, and carcinogenicity.
E. Denkhaus,K. Salnikow +1 more
TL;DR: This review provides an analysis of the current state in the field of nickel, a metal whose use is widening in modern technologies, and its known health related effects.
Journal ArticleDOI
Genetic and epigenetic mechanisms in metal carcinogenesis and cocarcinogenesis: nickel, arsenic, and chromium.
TL;DR: Overall, metal carcinogenesis appears to require the formation of specific metal complexes, chromosomal damage, and activation of signal transduction pathways promoting survival and expansion of genetically/epigenetically altered cells.
Journal Article
Nickel, its adverse health effects & oxidative stress.
TL;DR: A selective review on nickel and effect of its acute, subchronic and chronic doses on certain metabolically active tissues in human as well as animals is presented.
Journal ArticleDOI
Carcinogenic nickel silences gene expression by chromatin condensation and DNA methylation: a new model for epigenetic carcinogens.
Yong-Woo Lee,Catherine B. Klein,Biserka Kargacin,Konstantin Salnikow,Jun Kitahara,Karol Dowjat,Anatoly Zhitkovich,N T Christie,Max Costa +8 more
TL;DR: It is proposed that DNA condensation and methylation result in heterochromatinization of the gpt sequence with subsequent inheritance of the now silenced gene, which further supports the emerging theory that nickel is a human carcinogen that can alter gene expression by enhanced DNA methylation and compaction, rather than by mutagenic mechanisms.
References
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Journal ArticleDOI
Revised methods for the salmonella mutagenicity test
Dorothy M. Maron,Bruce N. Ames +1 more
TL;DR: Two new tester strains, a frameshift strain and a strain carrying an ochre mutation on a multicopy plasmid (TA102), are added to the standard tester set and two substitutions are made in diagnostic mutagens to eliminate MNNG and 9-aminoacridine.
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A new Salmonella tester strain (TA102) with A X T base pairs at the site of mutation detects oxidative mutagens
TL;DR: A new tester strain, TA102, is described as an addition to the set of strains for the Salmonella/microsome mutagenicity test, which detects a variety of oxidative mutagens, including x-rays, bleomycin, hydrogen peroxide and other hydroperoxides, streptonigrin and other quinones, and phenylhydrazine.
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Mutagen testing using TRP+ reversion in Escherichia coli.
Michael H.L. Green,W.J. Muriel +1 more
TL;DR: Escherichia coli strain WP2 and its repair-deficient derivatives are suitable strains for mutagen screening because agents which cause base substitution mutations can be shown to increase the frequency of Trp+ revertants.
Journal ArticleDOI
Mutagenic activities of metal compounds in bacteria.
TL;DR: In the present report, 56 metal compounds were tested by the rec-assay and their capacities to induce reversions in E. coli Trp/sup -/ strains possessing different DNA repair pathways were examined.
Journal ArticleDOI
Rec assay and mutagenicity studies on metal compounds.
TL;DR: Reverse mutation assays with Escherichia coli and Salmonella strains showed that compounds of rhodium, tellurium and platinum are potent mutagens.