Journal ArticleDOI
Mycoplasma genitalium: a review:
TLDR
The association of M. genitalium with non-specific urethritis is now well established, but the evidence supporting its role in both male and female infertility remains inconclusive and the recommended treatment is azithromycin as a single 1 gm dose.Abstract:
Mycoplasma genitalium (M. genitalium)was first isolated from the urethral swabs of two symptomatic men with urethritis in 1980. Published prevalence rates vary greatly between populations studied. A number of urogenital conditions have been ascribed toM. genitalium, which is recognised to cause a sexually transmitted infection. The association of M. genitalium with non-specific urethritis is now well established, but the evidence supporting its role in both male and female infertility remains inconclusive. Laboratory methods are challenging and there is a lack of test standardisation. The recommended treatment of the infection is azithromycin as a single 1 gm dose. However, in recent years macrolide resistance has been observed. More studies are required to establish the clinical importance of M. genitaliumin urogenital conditions, particularly infertility, and to establish the role for screening and treatment in high-risk populations.read more
Citations
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Journal ArticleDOI
Antimicrobial-resistant sexually transmitted infections: gonorrhoea and Mycoplasma genitalium.
Magnus Unemo,Jørgen Skov Jensen +1 more
TL;DR: Clinicians need to be aware of the current guidelines on diagnostic procedures, recommended treatment regimens, as well as therapeutic options for multidrug-resistant bacteria, and elucidate how AMRs compromise treatment effectiveness, guiding research for effective future therapies.
Journal ArticleDOI
Management of Mycoplasma genitalium infections – can we hit a moving target?
TL;DR: There is a critical need for trials of combinations of existing registered drugs and new antimicrobial compounds, implementation of diagnostic testing combined with molecular detection of resistance, and antimicrobial surveillance.
Journal ArticleDOI
Chlamydia trachomatis and Genital Mycoplasmas: Pathogens with an Impact on Human Reproductive Health
TL;DR: The role of genital mycoplasmas in development of PID, TFI, and EP requires further evaluation, but growing evidence supports a significant role for these in the pathogenesis of chorioamnionitis, premature membrane rupture, and preterm labor in pregnant woman.
Journal ArticleDOI
Evaluation of the new AmpliSens multiplex real-time PCR assay for simultaneous detection of Neisseria gonorrhoeae, Chlamydia trachomatis, Mycoplasma genitalium, and Trichomonas vaginalis.
Tatiana Rumyantseva,Daniel Golparian,Christian Steczkó Nilsson,Emma M. Johansson,My Falk,Hans Fredlund,Alje P. van Dam,Alexander Guschin,Magnus Unemo +8 more
TL;DR: The new CE‐marked multiplex real‐time AmpliSens N.vaginalis‐MULTIPRIME‐FRT PCR assay demonstrated high sensitivity and excellent specificity for the detection of C.gonorrhoeae/C.trachomatis/M.genitalium/T.
Journal ArticleDOI
Emergence of Mycoplasma genitalium strains showing mutations associated with macrolide and fluoroquinolone resistance in the region Dresden, Germany
TL;DR: Among 323 specimens from male patients with symptoms of non-gonococcal urethritis, Mycoplasma genitalium was detected in 19 samples by real-time PCR, indicating quinolone resistance of two strains.
References
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