Book ChapterDOI
Nanodimensional and Nanocrystalline Calcium Orthophosphates
TLDR
This chapter describes current state-of-the-art and recent developments on the subject of nanodimensional CaPO4, starting from synthesis and characterization to biomedical and clinical applications.Abstract:
Nano-scaled particles and crystals play very important roles in biological systems. For example, calcium orthophosphates (CaPO4) with nano-size dimensions represent the basic inorganic building blocks of bones and teeth of mammals. According to recent discoveries in biomineralization, zillions of nanodimensional crystals of biological apatites are nucleated in body fluids, and afterward, they are self-assembled into these complex structures. In addition, both a greater viability and a better proliferation of various types of cells have been detected on smaller crystals of CaPO4. All these effects are due to the higher surface-to-volume ratio, increased reactivity, and biomimetic morphologies of the nano-scaled particles. Thus, the nano-sized and nanocrystalline forms of CaPO4 have a great potential to revolutionize the hard tissue engineering field, starting from bone repair and augmentation to controlled drug delivery systems. Therefore, preparation and application of nanodimensional CaPO4 are the important topics in modern material science, and such formulations have been already tested clinically for various purposes. Currently, more efforts are focused on the possibility of combining nano-scaled CaPO4 with cells, drugs, and other biologically active substances for multipurpose applications. This chapter describes current state-of-the-art and recent developments on the subject, starting from synthesis and characterization to biomedical and clinical applications.read more
Citations
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Journal ArticleDOI
Calcium Phosphate Bioceramics: A Review of Their History, Structure, Properties, Coating Technologies and Biomedical Applications.
Noam Eliaz,Noah Metoki +1 more
TL;DR: A wide variety of CaPs are presented, from the individual phases to nano-CaP, biphasic and triphasic CaP formulations, composite CaP coatings and cements, functionally graded materials (FGMs), and antibacterial CaPs.
Journal ArticleDOI
Calcium Orthophosphate-Based Bioceramics
TL;DR: Current biomedical applications of calcium orthophosphate bioceramics include bone augmentations, artificial bone grafts, maxillofacial reconstruction, spinal fusion, periodontal disease repairs and bone fillers after tumor surgery.
Journal ArticleDOI
Calcium orthophosphate bioceramics
TL;DR: Current biomedical applications of CaPO4-based bioceramics include bone augmentations, artificial bone grafts, maxillofacial reconstruction, spinal fusion, periodontal disease repairs and bone fillers after tumor surgery, and future applications comprise drug delivery and tissue engineering purposes.
Journal Article
Colloidal nanocrystal synthesis and the organic-inorganic interface
Yadong Yin,A. Paul Alivisatos +1 more
TL;DR: In this paper, the authors review what is known about nanocrystal growth and outline strategies for controlling it, and present a review of the current state-of-the-art in this area.
Journal ArticleDOI
Dissolution mechanism of calcium apatites in acids: A review of literature.
TL;DR: An attempt to combine the findings obtained by different researchers was performed which resulted in creation of the general description of apatite dissolution in acids, which creates a new methodological approach to investigate reaction mechanisms based on sets of affine data.
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