Natural history, predictors and outcomes of depression after stroke: systematic review and meta-analysis
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TLDR
Major predictors of depression are disability, depression pre-stroke, cognitive impairment, stroke severity and anxiety, and lower quality of life, mortality and disability are independent outcomes of depression after stroke.Abstract:
Background
Depression after stroke is a distressing problem that may be associated with other negative health outcomes.
Aims
To estimate the natural history, predictors and outcomes of depression after stroke.
Method
Studies published up to 31 August 2011 were searched and reviewed according to accepted criteria.
Results
Out of 13 558 references initially found, 50 studies were included. Prevalence of depression was 29% (95% CI 25–32), and remains stable up to 10 years after stroke, with a cumulative incidence of 39–52% within 5 years of stroke. The rate of recovery from depression among patients depressed a few months after stroke ranged from 15 to 57% 1 year after stroke. Major predictors of depression are disability, depression pre-stroke, cognitive impairment, stroke severity and anxiety. Lower quality of life, mortality and disability are independent outcomes of depression after stroke.
Conclusion
Interventions for depression and its potential outcomes are required.read more
Citations
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Book ChapterDOI
A National Survey
TL;DR: In this paper, a broad framework within which to consider the importance of managerial and organisational integration is provided, and a wider educational and training issues which influence not only conceptual skills but also attitude are raised.
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Post-Stroke Depression: A Review
TL;DR: Poststroke depression has been recognized by psychiatrists for more than 100 years, but controlled systematic studies did not begin until the 1970s and recent meta-analyses of randomized controlled trials for the treatment and prevention of PSD have demonstrated the efficacy of antidepressants.
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Poststroke Depression: A Scientific Statement for Healthcare Professionals From the American Heart Association/American Stroke Association
Amytis Towfighi,Bruce Ovbiagele,Nada El Husseini,Maree L. Hackett,Ricardo E. Jorge,Brett M. Kissela,Pamela H. Mitchell,Lesli E. Skolarus,Mary A. Whooley,Linda S. Williams +9 more
TL;DR: This multispecialty statement provides a comprehensive review of the current evidence and gaps in current knowledge of the epidemiology, pathophysiology, outcomes, management, and prevention of PSD, and provides implications for clinical practice.
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Post-stroke depression: Mechanisms and pharmacological treatment.
TL;DR: This review will address the various areas of epidemiology, pathophysiology, preventive and therapeutic strategies for post‐stroke depression, as well as the effect of depression as risk factor for stroke.
Journal ArticleDOI
Neuropsychiatric outcomes of stroke.
Maree L. Hackett,Maree L. Hackett,Sebastian Köhler,John T. O'Brien,John T. O'Brien,Gillian Mead +5 more
TL;DR: The most common neuropsychiatric outcomes of stroke are depression, anxiety, fatigue, and apathy, which each occur in at least 30% of patients and have substantial overlap of prevalence and symptoms.
References
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TL;DR: A checklist contains specifications for reporting of meta-analyses of observational studies in epidemiology, including background, search strategy, methods, results, discussion, and conclusion should improve the usefulness ofMeta-an analyses for authors, reviewers, editors, readers, and decision makers.
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TL;DR: The stroke profile can be used for evaluation of the risk of stroke and suggestion of risk factor modification to reduce risk.
Journal ArticleDOI
Predictors of Depression after Stroke: A Systematic Review of Observational Studies
TL;DR: A systematic review of all published nonexperimental studies (to June 2004) with prospective consecutive patient recruitment and quantification of depressive symptoms/illness after stroke was conducted in this article.