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Nebivolol induces parallel improvement of left ventricular filling pressure and coronary flow reserve in uncomplicated arterial hypertension.

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TLDR
The association between changes of CFR and those of LVFP indicates a possible common denominator between improvement of coronary microvascular function and myocardial stimulation of nitric oxide release induced by the drug.
Abstract
PurposeOur aim was to analyze the effects of 3-month antihypertensive therapy by nebivolol, a β-blocking agent with nitric oxide-mediated vasodilatory properties, on coronary flow reserve (CFR) and left ventricular filling pressure (LVFP) in uncomplicated arterial hypertension.MethodsTwenty newly di

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Journal ArticleDOI

Reappraisal of European guidelines on hypertension management: a European Society of Hypertension Task Force document.

TL;DR: The objective of this study was to establish a baseline for the design of a systematic literature review of this type of treatment for high blood pressure using a simple, straightforward, and scalable procedure.
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Diagnosis and Management of Left Ventricular Diastolic Dysfunction in the Hypertensive Patient

TL;DR: Comprehensive assessment of diastolic function should be done not by a simple classification of DD progression but by estimating the degree of LV filling pressure (FP), a true determinant of symptoms and prognosis.
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Non-invasive quantification of coronary vascular dysfunction for diagnosis and management of coronary artery disease

TL;DR: Current approaches to the quantification of coronary vascular function and the evidence supporting its potential diagnostic and prognostic implications are discussed with a particular focus on ischemic heart disease.
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Practical approach to diastolic dysfunction in light of the new guidelines and clinical applications in the operating room and in the intensive care.

TL;DR: The present review aims at rationalizing the applicability of the recent recommendations to the perioperative and ICU areas, discussing the clinical meaning and echocardiographic findings of different grades of LVDD, describing the impact ofLVDD on patients’ outcomes and providing some hints on the management of patients with LVDd.
References
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Journal ArticleDOI

Doppler Tissue Imaging: A Noninvasive Technique for Evaluation of Left Ventricular Relaxation and Estimation of Filling Pressures

TL;DR: Mitral E velocity, corrected for the influence of relaxation (i.e., the E/Ea ratio), relates well to mean PCWP and may be used to estimate LV filling pressures.
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Clinical Utility of Doppler Echocardiography and Tissue Doppler Imaging in the Estimation of Left Ventricular Filling Pressures A Comparative Simultaneous Doppler-Catheterization Study

TL;DR: The combination of tissue Doppler imaging of the mitral annulus and mitral inflow velocity curves provides better estimates of LV filling pressures than other methods (pulmonary vein, preload reduction), however, accurate prediction of filling pressures for an individual patient requires a stepwise approach incorporating all available data.
Journal ArticleDOI

Relation of Left Ventricular Mass and Geometry to Morbidity and Mortality in Uncomplicated Essential Hypertension

TL;DR: Echocardiographically determined left ventricular mass and geometry stratify risk in patients with essential hypertension independently of and more strongly than blood pressure or other potentially reversible risk factors and may help to stratify the need for intensive treatment.
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