Journal ArticleDOI
Neoadjuvant Concurrent Chemoradiation for Advanced Esthesioneuroblastoma: A Case Series and Review of the Literature
Sohrab Sohrabi,Joseph J. Drabick,Henry Crist,David M. Goldenberg,Jonas M. Sheehan,Heath B. Mackley +5 more
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TLDR
Two cases of advanced ENB are presented at this institution treated with a preoperative concurrent radiochemotherapy in a manner akin to that of small-cell carcinoma of the lung.Abstract:
Esthesioneuroblastoma (ENB) is a rare malignancy arising from the olfactory epithelium of the nasal vault. ENB accounts for 3% to 6% of all intranasal tumors and has the best prognosis among sinonasal malignancies with neuroendocrine differentiation. The optimal treatment continues to be controversial, but the benefit of adjuvant therapy, particularly radiotherapy, has been well described in the literature. The largest reported series evaluated neoadjuvant radiotherapy of 50 Gy, with or without neoadjuvant chemotherapy, and found improved resectability with improved patient survival. We present two cases of advanced ENB at our institution treated with a preoperative concurrent radiochemotherapy in a manner akin to that of small-cell carcinoma of the lung.read more
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Optimization of long-term outcomes for patients with esthesioneuroblastoma.
Thomas J. Ow,Ehab Y. Hanna,Dianna B. Roberts,Nicholas B. Levine,Adel K. El-Naggar,David I. Rosenthal,F. DeMonte,Michael E. Kupferman +7 more
TL;DR: The purpose of this study was to review the long‐term outcomes of patients diagnosed with esthesioneuroblastoma treated at a single institution to determine factors associated with improved disease control and survival.
Journal ArticleDOI
Low- and high-grade esthesioneuroblastomas display a distinct natural history and outcome
TL;DR: Low and high-grade ENB display distinct patterns at presentation and relapse, leading to different prognosis, therefore, they may be regarded as distinct entities.
Journal ArticleDOI
Esthesioneuroblastoma: A Comprehensive Review of Diagnosis, Management, and Current Treatment Options.
Brian Fiani,Syed A. Quadri,Alessandra Cathel,Mudassir Farooqui,Anirudh Ramachandran,Imran Siddiqi,Hammad Ghanchi,Atif Zafar,Blake Berman,Javed Siddiqi +9 more
TL;DR: Surgical resection followed by radiotherapy is the current standard for treatment for higher-grade lesions and endoscopic endonasal approach is gaining further recognition with more favorable outcomes and better survival rates than open surgery.
Journal ArticleDOI
Acute toxicity in comprehensive head and neck radiation for nasopharynx and paranasal sinus cancers: cohort comparison of 3D conformal proton therapy and intensity modulated radiation therapy.
TL;DR: Proton therapy was associated with significantly reduced radiation dose to assessed non-target normal tissues and a reduced rate of gastrostomy tube dependence and opioid pain medication requirements and warrants further evaluation in larger studies.
Journal ArticleDOI
Multimodal treatment and long-term outcome of patients with esthesioneuroblastoma.
A. Modesto,A. Modesto,Pierre Blanchard,Yungan Tao,Michel Rives,François Janot,E. Serrano,Adil Benlyazid,Joël Guigay,F.R. Ferrand,Jean Pierre Delord,Jean Bourhis,Nicolas Daly-Schveitzer +12 more
TL;DR: The high risk of locoregional failure in ENB justifies the use of multimodal therapy and elective LNI might prevent regional failure in locally advanced disease.
References
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Journal ArticleDOI
Hyperfractionated Irradiation with or without Concurrent Chemotherapy for Locally Advanced Head and Neck Cancer
David M. Brizel,Mary E. Albers,Samuel R. Fisher,Richard L. Scher,William J. Richtsmeier,Vera Hars,Stephen L. George,Andrew T. Huang,Leonard R. Prosnitz +8 more
TL;DR: Combined treatment for advanced head and neck cancer is more efficacious and not more toxic than hyperfractionated irradiation alone.
Journal ArticleDOI
Olfactory neuroblastoma—A clinical analysis of 17 cases
TL;DR: Of 17 patients in this series, 13 or 76% were alive without disease following treatment by surgery, irradiation, and combination of these two methods, and a treatment policy for this disease is presented.
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Simultaneous radiochemotherapy versus radiotherapy alone in advanced head and neck cancer: a randomized multicenter study.
Wendt Tg,Gerhard G. Grabenbauer,Claus Rödel,H J Thiel,H Aydin,R Rohloff,T P Wustrow,Heinrich Iro,C Popella,A Schalhorn +9 more
TL;DR: Concomitant CT offered improved disease control and survival in advanced head and neck cancer patients due to increased acute toxicity, more supportive care is demanded when CT is given simultaneously.
Journal ArticleDOI
Overview of Combined Modality Therapies for Head and Neck Cancer
Isaiah W. Dimery,W. K. Hong +1 more
TL;DR: It is concluded that curability of nasopharyngeal carcinoma with a combined modality approach appears to be an achievable goal, but adequate evaluation in large-scale randomized trials is hampered by low accrual to clinical trials.