Neonatal and Maternal Outcome of COVID-19 positive women in Sri Lanka: Secondary Analysis using National COVID-19 Positive Pregnant Women Surveillance
Malith Kumarasinghe,Kaushalya Kasturiaratchi,Hemali Jayakody,S. Irfaan,Wijaya Samarasinghe,Hansini Dassanayake,Sanjeewa Godakandage,Chamini K. De Silva +7 more
TLDR
Increased severity of maternal COVID-19 infection and pre-pregnancy overweight/ obesity were associated with many adverse pregnancy and neonatal outcomes and close observation and aggressive management of CO VID-19 among the pregnant women should be considered to reduce the risk of progressing to severe illness.Abstract:
Objectives This study aims to describe the population level data on neonatal and maternal outcomes of COVID-19 positive pregnant women of Sri Lanka by secondary analysis using National COVID-19 Positive Pregnant Women Surveillance. Design Secondary analysis of surveillance data from the National COVID-19 positive pregnant women surveillance, Sri Lanka. Data of all pregnant women whose maternal and neonatal outcomes were reported in National Surveillance from 1st March 2020 to 31st October 2021 were included in the study. Associated factors for maternal and neonatal outcomes, namely POA at delivery, mode of delivery, birthweight, immediate place of newborn care, congenital abnormalities, and condition of neonate at completion of one month were calculated using univariate and multivariate Odds ratios. Results Maternal COVID-19 infection reported preterm birth rate of 11.9%, LSCS rate of 54.5%, low birthweight rate16.5% and 8.3% of the newborns requiring intensive care. Neonatal mortality rate was 9 per 1000 live births. Pre-pregnancy overweight and obesity increased the risk of preterm delivery compared to pregnant women with normal BMI by 46.7% (AOR=1.467, CI=1.111-1.938, P=0.007). In contrast, the risk of preterm delivery reduced by 82.4% (AOR=0.176, CI=0.097-0.317, p<0.001) and presence of any type of congenital abnormalities in newborns by 72.4% among the COVID-19 positive women who required only inward treatment in comparison to women with severe COVID-19 infection requiring intensive care (AOR=0.276, CI=0.112-0.683, p=0.005). Conclusion Increased severity of maternal COVID-19 infection and pre-pregnancy overweight/ obesity were associated with many adverse pregnancy and neonatal outcomes. Therefore, close observation and aggressive management of COVID-19 among the pregnant women should be considered to reduce the risk of progressing to severe illness.read more
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Outcome of coronavirus spectrum infections (SARS, MERS, COVID-19) during pregnancy: a systematic review and meta-analysis.
Daniele Di Mascio,Asma Khalil,Gabriele Saccone,Giuseppe Rizzo,Danilo Buca,Marco Liberati,Jacopo Vecchiet,Luigi Nappi,Giovanni Scambia,Vincenzo Berghella,Francesco D'Antonio +10 more
TL;DR: Pregnancy and perinatal outcomes of Coronavirus (CoV) spectrum infections, and particularly COVID-19 disease due to SARS-COV-2 infection during pregnancy were reported, including miscarriage, preterm birth, pre-eclampsia, pre term prelabor rupture of membranes, fetal growth restriction, and mode of delivery.
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Rebecca Pierce-Williams,Julia Burd,Laura Felder,Rasha Khoury,Peter S. Bernstein,Karina Avila,Christina A. Penfield,Ashley S. Roman,Chelsea DeBolt,Joanne Stone,Angela Bianco,Adina R. Kern-Goldberger,Adi Hirshberg,Sindhu K. Srinivas,Jenani S. Jayakumaran,Justin S. Brandt,Hannah Anastasio,Meredith L. Birsner,Devon S. O’Brien,Harish M. Sedev,Cara D. Dolin,William T. Schnettler,Anju Suhag,Shabani Ahluwalia,Reshama Navathe,Adeeb Khalifeh,Kathryn Anderson,Vincenzo Berghella +27 more
TL;DR: The clinical course of severe and critical infection in hospitalized pregnant women with positive laboratory testing for SARS-CoV2 is described, followed by the median disease day on which these outcomes occurred after the onset of symptoms.
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Maternal and neonatal outcomes associated with COVID-19 infection: A systematic review.
Vinayak Smith,Densearn Seo,Ritesh Rikain Warty,Olivia Payne,Mohamed Salih,Ken Lee Chin,Ken Lee Chin,Richard Ofori-Asenso,Sathya Krishnan,Fabricio da Silva Costa,Fabricio da Silva Costa,Beverley Vollenhoven,Euan M. Wallace +12 more
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Journal ArticleDOI
Impact of COVID-19 on maternal and neonatal outcomes: a systematic review and meta-analysis.
Francesca Di Toro,Mattheus Gjoka,Giovanni Di Lorenzo,Davide De Santo,Francesco De Seta,Gianpaolo Maso,Francesco Maria Risso,Federico Romano,Uri Wiesenfeld,Roberto Levi-D'Ancona,Luca Ronfani,Giuseppe Ricci +11 more
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