Neural Ensembles in CA3 Transiently Encode Paths Forward of the Animal at a Decision Point
Adam Johnson,A. David Redish +1 more
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The data suggest that the hippocampus does not represent space as a passive computation, but rather that hippocampal spatial processing is an active process likely regulated by cognitive mechanisms.Abstract:
Neural ensembles were recorded from the CA3 region of rats running on T-based decision tasks. Examination of neural representations of space at fast time scales revealed a transient but repeatable phenomenon as rats made a decision: the location reconstructed from the neural ensemble swept forward, first down one path and then the other. Estimated representations were coherent and preferentially swept ahead of the animal rather than behind the animal, implying it represented future possibilities rather than recently traveled paths. Similar phenomena occurred at other important decisions (such as in recovery from an error). Local field potentials from these sites contained pronounced theta and gamma frequencies, but no sharp wave frequencies. Forward-shifted spatial representations were influenced by task demands and experience. These data suggest that the hippocampus does not represent space as a passive computation, but rather that hippocampal spatial processing is an active process likely regulated by cognitive mechanisms.read more
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References
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Book
Reinforcement Learning: An Introduction
TL;DR: This book provides a clear and simple account of the key ideas and algorithms of reinforcement learning, which ranges from the history of the field's intellectual foundations to the most recent developments and applications.
Book
The Hippocampus as a Cognitive Map
John O'Keefe,Lynn Nadel +1 more
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Loss of recent memory after bilateral hippocampal lesions.
TL;DR: The results of these studies point to the importance of the hippocampal complex for normal memory function in patients who had undergone similar, but less radical, bilateral medial temporallobe resections, and as a warning to others of the risk to memory involved in bilateral surgical lesions of the hippocampusal region.
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TL;DR: The role of the hippocampus is considered, which is needed temporarily to bind together distributed sites in neocortex that together represent a whole memory.
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The hippocampus as a cognitive map
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