Neuroimaging of Cognitive Dysfunction and Depression in Aging Retired National Football League Players: A Cross-sectional Study
John Hart,Michael A. Kraut,Michael A. Kraut,Kyle B. Womack,Jeremy F. Strain,Nyaz Didehbani,Elizabeth K. Bartz,Heather Conover,Sethesh Mansinghani,Hanzhang Lu,C. Munro Cullum +10 more
Reads0
Chats0
TLDR
This paper found significant differences in white matter abnormalities and changes in regional cerebral blood flow in cognitively impaired and depressed retired players compared with their respective healthy matched controls, indicating that cognitive deficits and depression appear to be more common in aging former NFL players compared to healthy controls.Abstract:
OBJECTIVES To assess cognitive impairment and depression in aging former professional football (National Football League [NFL]) players and to identify neuroimaging correlates of these dysfunctions. DESIGN We compared former NFL players with cognitive impairment and depression, cognitively normal retired players who were not depressed, and matched healthy control subjects. SETTING Research center in the North Texas region of the United States. PATIENTS Cross-sectional sample of former NFL players with and without a history of concussion recruited from the North Texas region and age-, education-, and IQ-matched controls. Thirty-four retired NFL players (mean age, 61.8 years) underwent neurological and neuropsychological assessment. A subset of 26 players also underwent detailed neuroimaging; imaging data in this subset were compared with imaging data acquired in 26 healthy matched controls. MAIN OUTCOME MEASURES Neuropsychological measures, clinical diagnoses of depression, neuroimaging mea-sures of white matter pathology, and a measure of cerebral blood flow. RESULTS Of the 34 former NFL players, 20 were cognitively normal. Four were diagnosed as having a fixed cognitive deficit; 8, mild cognitive impairment; 2, dementia; and 8, depression. Of the subgroup in whom neuroimaging data were acquired, cognitively impaired participants showed the greatest deficits on tests of naming, word finding, and visual/verbal episodic memory. We found significant differences in white matter abnormalities in cognitively impaired and depressed retired players compared with their respective controls. Regional blood flow differences in the cognitively impaired group (left temporal pole, inferior parietal lobule, and superior temporal gyrus) corresponded to regions associated with impaired neurocognitive performance (problems with memory, naming, and word finding). CONCLUSIONS Cognitive deficits and depression appear to be more common in aging former NFL players compared with healthy controls. These deficits are correlated with white matter abnormalities and changes in regional cerebral blood flow.read more
Citations
More filters
Journal ArticleDOI
Evaluation of Visual-Evoked Cerebral Metabolic Rate of Oxygen as a Diagnostic Marker in Multiple Sclerosis
Nicholas A. Hubbard,Yoel Sanchez Araujo,Camila Caballero,Minhui Ouyang,Monroe P. Turner,Lyndahl Himes,Shawheen Faghihahmadabadi,Binu P. Thomas,Binu P. Thomas,John Hart,Hao Huang,Darin T. Okuda,Bart Rypma +12 more
TL;DR: Assessment of the accuracy of a new neuroimaging marker, visual-evoked cerebral metabolic rate of oxygen (veCMRO2), in classifying multiple sclerosis patients and closely age- and sex-matched healthy control participants demonstrated an encouraging first step toward establishing veCM RO2 as a neurodiagnostic marker of MS.
Dissertation
Recovery from Concussion in a Cohort of Male High School Students
TL;DR: In this paper, a retrospective and prospective longitudinal cohort design was used to describe recovery time from concussion and the contribution of history of learning difficulty, history of concussion and school grade of student on recovery patterns in a cohort of 116 male high school students.
Journal ArticleDOI
Comparison of Neurocognitive Changes Over One Competitive Season in Adolescent Contact and Non-contact Athletes
Ashley S Long,Janet P. Niemeier,Andrew McWilliams,Charity G Patterson,Paul B. Perrin,Megan Templin,David E. Price +6 more
Journal ArticleDOI
Individual and cumulative health afflictions are associated with greater impairment in physical and mental function in former professional American style football players
Adam S. Tenforde,Adam S. Tenforde,Bryan Cortez,Elaine Coughlan-Gifford,Rachel Grashow,Jillian Baker,Aaron L. Baggish,Alvaro Pascual-Leone,Lee M. Nadler,Frank E. Speizer,Herman A. Taylor,Marc G. Weisskopf,Ross Zafonte,Ross Zafonte +13 more
TL;DR: In this paper, the authors evaluated the association of afflictions to physical and mental function in former American style football players and found that cumulative affliction is associated with a worse physical function.
References
More filters
Journal ArticleDOI
Clinical diagnosis of Alzheimer's disease : report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
Guy M. McKhann,David A. Drachman,Marshall F. Folstein,Robert Katzman,Donald L. Price,Emanuel M. Stadlan +5 more
TL;DR: The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available.
Journal ArticleDOI
Fast robust automated brain extraction
TL;DR: An automated method for segmenting magnetic resonance head images into brain and non‐brain has been developed and described and examples of results and the results of extensive quantitative testing against “gold‐standard” hand segmentations, and two other popular automated methods.
Journal ArticleDOI
Mild Cognitive Impairment: Clinical Characterization and Outcome
Ronald C. Petersen,Glenn E. Smith,Stephen C. Waring,Robert J. Ivnik,Eric G. Tangalos,Emre Kokmen +5 more
TL;DR: Patients who meet the criteria for MCI can be differentiated from healthy control subjects and those with very mild AD, and appear to constitute a clinical entity that can be characterized for treatment interventions.
Related Papers (5)
The spectrum of disease in chronic traumatic encephalopathy
Ann C. McKee,Thor D. Stein,Thor D. Stein,Christopher J. Nowinski,Robert S. Stern,Daniel H. Daneshvar,Victor E. Alvarez,H. J. Lee,Garth F. Hall,Sydney M. Wojtowicz,Sydney M. Wojtowicz,Christine M. Baugh,David O. Riley,Caroline A. Kubilus,Kerry Cormier,Matthew A. Jacobs,Brett Martin,Carmela R. Abraham,Tsuneya Ikezu,Robert Ross Reichard,Benjamin Wolozin,Andrew E. Budson,Andrew E. Budson,Lee E. Goldstein,Neil W. Kowall,Robert C. Cantu +25 more