Journal ArticleDOI
Neuronally activated metabolism of brain serotonin: effect of lithium.
TLDR
Pretreatment of rats with lithium chloride increased the rate of brain serotonin turnover and was accentuated by electrical stimulation of serotonincontaining neuronal perikarya in the dorsal raphe nucleus.About:
This article is published in Life Sciences.The article was published on 1970-03-01. It has received 94 citations till now. The article focuses on the topics: Lithium chloride & Lithium (medication).read more
Citations
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Aggression in humans correlates with cerebrospinal fluid amine metabolites
TL;DR: Cerebrospinal fluid of the major central metabolites of serotonin, norepinephrine, and dopamine--5HIAA, 3-methoxy-4-hydroxy=phenylglycol (MHPG), and homovanillic acid (HVA), respectively--were studied in a group of 26 age-similar military men with no history of major psychiatric illness, but with various personality disorders and difficulties adjusting to military life.
Journal ArticleDOI
L-Tryptophan in Mania: Contribution to a Permissive Hypothesis of Affective Disorders
TL;DR: Five manic patients were treated with chlorpromazine hydrochloride, then with L-tryptophan, and five with LTP first, then CPZ, in a double-blind, placebo-controlled crossover study, finding LTP was slightly superior to CPZ in all regards.
Journal ArticleDOI
Effect of Lithium on Human Aggression
TL;DR: A clinical trial of lithium on human aggressive behaviour found it to have an inhibitory effect on aggressive behaviour and on the sexual and aggressive behaviour seen with p-chlorophenylalanine.
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Lithium and serotonin function: implications for the serotonin hypothesis of depression.
TL;DR: Preclinical evidence of lithium's effects on 5-HT function at the levels of precursor uptake, synthesis, storage, catabolism, release, receptors, and receptor-effector interactions suggests that lithium's primary actions on5-HT may be presynaptic, with many secondary postsynaptic effects.
Journal ArticleDOI
The behavioral actions of lithium in rodent models: leads to develop novel therapeutics.
TL;DR: A discussion of various molecular mechanisms by which these lithium-sensitive behaviors may be mediated are mediated, and the ways in which rat and mouse models can be used more effectively in the future to address persistent questions about the therapeutically relevant molecular actions of lithium.
References
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Journal ArticleDOI
Ascending Monoamine Neurons to the Telencephalon and Diencephalon
TL;DR: A number of ascending monoamine neuron systems from the lower brain stem are demonstrated and mapped out by studying the anterograde and retrograde changes that occur in these neurons after various types of brain lesions.
Journal ArticleDOI
Lithium As a Prophylactic Agent: Its Effect Against Recurrent Depressions and Manic-Depressive Psychosis
TL;DR: In order to demonstrate prophylactic drug action in a disorder such as manicdepressive psychosis, which is characterized by a capricious and largely unpredictable course, one must study a large number of patients who have a sufficiently high risk of relapse and who are observed for relapse.
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Lysergic Acid Diethylamide: Sensitive Neuronal Units in the Midbrain Raphe
TL;DR: An inhibition of neurons containing serotonin after administration of d-lysergic acid diethylamide could account for the decreased metabolism of serotonin produced by this drug.
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Serotonin: release in the forebrain by stimulation of midbrain raphé
TL;DR: Electrical stimulation of the midbrain raph�, an area in which neuronal perikarya containing serotonin are aggregated, produces an increase in 5-hydroxyindoleacetic acid and a decrease in serotonin in the forebrain, indicating that serotonin inThe brain can be released via a specific neural pathway.
Journal ArticleDOI
Evoked Release of Norepinephrine and Serotonin from Brain Slices: Inhibition by Lithium
TL;DR: Stimulation-induced release of both labeled monoamines is diminished by the presence of lithium ions in the perfusing medium; related monovalent cations had no such effect.
Related Papers (5)
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