Open AccessJournal Article
Neuropathology of experimental allergic encephalomyelitis in inbred strains of mice.
TLDR
Ten inbred strains of mice were tested for their susceptibility to experimental allergic encephalomyelitis (EAE) after sensitization with mouse spinal cord in complete Freund's adjuvant followed by booster injections of Bordetella pertussis, and it was found that not all susceptible mice possessed the H-2s haplotype, but mice with an H-1q background (DBA1/J strain) were also susceptible.About:
This article is published in Laboratory Investigation.The article was published on 1980-08-01 and is currently open access. It has received 155 citations till now. The article focuses on the topics: Encephalomyelitis & Myelin.read more
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Reactive Astrocytes Form Scar-Like Perivascular Barriers to Leukocytes during Adaptive Immune Inflammation of the CNS
Rhonda R. Voskuhl,R. Scott Peterson,Bingbing Song,Yan Ao,Laurie Beth J. Morales,Seema K. Tiwari-Woodruff,Michael V. Sofroniew +6 more
TL;DR: Experimental evidence is provided that reactive astrocytes form scar-like perivascular barriers that restrict the influx of leukocytes into CNS parenchyma and protect CNS function during peripherally initiated, acquired immune inflammatory responses in the CNS.
Journal ArticleDOI
Adoptive transfer of myelin basic protein-sensitized T cells produces chronic relapsing demyelinating disease in mice
TL;DR: It is reported here that a single transfer of MBP-sensitized lymph node cells or T cells, in the absence of a peripheral antigen depot, leads to both acute EAE with significant primary demyelination, and chronic relapsing disease with lesions typical of demYelination over a long period.
Journal Article
IFN-gamma is critical to the control of murine autoimmune encephalomyelitis and regulates both in the periphery and in the target tissue: a possible role for nitric oxide
TL;DR: The data suggest that IFN-gamma down-regulates EAE by inducing inducible NO synthase and subsequently NO production, both by macrophages in the periphery and, by inference, microglia and astrocytes in the target tissue.
Journal ArticleDOI
Detecting axon damage in spinal cord from a mouse model of multiple sclerosis
Joong Hee Kim,Matthew D. Budde,Hsiao-Fang Liang,Robyn S. Klein,John H. Russell,Anne H. Cross,Sheng-Kwei Song +6 more
TL;DR: It is suggested that axonal damage is more widespread than myelin damage in the spinal cord white matter of mice with EAE and that in vivo DTI may provide a sensitive and specific measure of white matter injury.
Journal Article
Evidence for involvement of ICAM-1 and VCAM-1 in lymphocyte interaction with endothelium in experimental autoimmune encephalomyelitis in the central nervous system in the SJL/J mouse
TL;DR: Investigation of the expression of vascular adhesion molecules during the first stage of chronic inflammation in experimental autoimmune encephalomyelitis in the SJL/J mouse showed that the vascular endothelium in brains and spinal cords from diseased animals expressed high levels of vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion substance (ICAM) but no detectable mucosal addressin or peripheral lymph node addressin.
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Adoptive transfer of experimental allergic encephalomyelitis in SJL/J mice after in vitro activation of lymph node cells by myelin basic protein: requirement for Lyt 1+ 2- T lymphocytes.
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