Journal ArticleDOI
New anti‐tumor agents. 2. Benzopyranylamine compounds
TLDR
Pyrrolidine, morpholine and piperidine derived Mannich bases of types 1-3 react with acetone, propionaldehyde and butyraldehyde to form 2-methyl and 3-methylbenzopyrans of types 4-8 as mentioned in this paper.About:
This article is published in Journal of Heterocyclic Chemistry.The article was published on 1996-11-01. It has received 7 citations till now. The article focuses on the topics: Benzopyrans & Morpholine.read more
Citations
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The effects of spacer groups on the chelation characteristics of some new mannich polymers containing 8-hydroxyquinoline
TL;DR: In this article, a Mannich-type condensation of 8-hydroxyquinoline with formaldehyde and piperazine or N, N'-dimethylethylenediamine, respectively, was used to obtain two new chelate-forming polymers.
Journal ArticleDOI
Organocatalytic Asymmetric Friedel–Crafts Reaction of Sesamol with Isatins: Access to Biologically Relevant 3‐Aryl‐3‐hydroxy‐2‐oxindoles
TL;DR: The Friedel-Crafts reaction of electron-rich phenols with isatins was developed by employing bifunctional thiourea-tertiary amine organocatalysts to obtain biologically important 3-aryl-3-hydroxy-2-oxindole 11 in good enantiomeric excess and having a 1,2,3-triazole moiety.
Journal ArticleDOI
New anti-tumor agents. 3. phenolic benzopyran lactone and amine derivatives
TL;DR: In this paper, 2-Aminopyridine, sesamol and 4-hydroxy-3,5-dimethoxybenzaldehyde condense to form Mannic base 3b which reacts with tetronic acid to yield lactone 4c; this inhibits growth of tumors in NCI in vitro tests.
Journal ArticleDOI
Synthesis and chelation properties of some new mannich condensation polymers containing a salicylaldoxime group
TL;DR: In this article, a new oxime containing polymer, Poly(salicylaldoxime-3,5-diyl (N,N′-dimethylethylenediamine N, N′-bismethylene)), polymer 1, was prepared through a Mannich-type condensation of salicylldoxime with formaldehyde and N,N−dimethyltylheniamine, and polymer 2 was obtained by a similar Mannich condensation in presence of resorcinol as the crosslinker.
Patent
Glycosylated Warfarin Analogs and Uses Thereof
TL;DR: In this article, a set of glycosylated warfarin analogs which are useful as anti-tumor or anti-metastatic agents and as reagents for studying sugar uptake in cells are presented.
References
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Journal ArticleDOI
The National Cancer Institute: cancer drug discovery and development program.
TL;DR: An update on the NCI's revised cancer screen is accompanied by a brief summary of those new agents scheduled to be entered into clinical investigation in the near future.
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Methylenedioxy-benzopyran analogs of podophyllotoxin, a new synthetic class of antimitotic agents that inhibit tubulin polymerization
TL;DR: Despite their structural and functional similarities to podophyllotoxin, however, the methylenedioxy-benzopyran derivatives subtly differ from the natural product in their interaction with tubulin, for they stimulated rather than inhibited tubulin-dependent GTP hydrolysis.
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New anti-tumor agents. 1. heterocyclic benzodioxole lactones
TL;DR: In this article, the authors used Morpholino Mannich bases of types 5, 12 react with tetronic acid in aqueous acetic acid to yield uncyclized lactones of types 7, 13.
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The Meisenheimer complex of glutathione and trinitrobenzene. A potent inhibitor of the glutathione S-transferase from Galleria mellonella.
Alan G. Clark,Martin Sinclair +1 more
TL;DR: The Meisenheimer complex formed between reduced glutathione and 1,3,5-trinitrobenzene is characterised by an extinction coefficient at 470 nm of 20400 and by an association constant at pH 9.0 and at GSH concentrations greater than 1 mM, the inhibition of the enzyme became markedly non-hyperbolic.
Journal ArticleDOI
Mannich base derivatives of bioactive benzyl-1,3-benzodioxo-5-ols
TL;DR: 3,4-Methylenedioxyphenol (sesamol) reacts with equimolecular quantities of an aromatic aldehyde and morpholine or piperidine in methanol to give Mannich bases 7 and 8, related to insect growth regulators and anti-leukemic and antimitotic benzyl-1,3-benzodioxole derivatives.