Journal ArticleDOI
New automated synthesis of [18F]FP-CIT with base amount control affording high and stable radiochemical yield: a 1.5-year production report
Sang Ju Lee,Seung Jun Oh,Woo Yeon Moon,Moon Seok Choi,Jae Seung Kim,Dae Yoon Chi,Dae Hyuk Moon,Jin-Sook Ryu +7 more
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New [(18)F]FP-CIT automatic preparation method showed high and reliable radiochemical yield and it could have enough >35 patient doses of [(18]F] FP-C IT from one production.About:
This article is published in Nuclear Medicine and Biology.The article was published on 2011-05-01. It has received 16 citations till now.read more
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Journal ArticleDOI
Hydrogen-bond promoted nucleophilic fluorination: concept, mechanism and applications in positron emission tomography
Ji-Woong Lee,Maria Teresa Oliveira,Hyeong Bin Jang,Sungyul Lee,Dae Yoon Chi,Dong Wook Kim,Choong Eui Song +6 more
TL;DR: Simultaneous dual activation of reacting partners by intermolecular hydrogen bonding and the enhancement of the "effective fluoride nucleophilicity", which is Nature's biocatalytic approach with the fluorinase enzyme, are the key to this unprecedentedly successful nucleophilic fluorination.
Journal ArticleDOI
High Yielding [ 18 F]Fluorination Method by Fine Control of the Base
TL;DR: In this article, an exact amount of base must be added to the reactor without appli-cation of an anion exchange cartridge, but this method has some problems with controlling the number of base additions.
Journal ArticleDOI
Feasibility of PET Template-Based Analysis on F-18 FP-CIT PET in Patients with De Novo Parkinson’s Disease
Eugene Jeong,Sun Young Oh,Kisoo Pahk,Chan-Nyoung Lee,Kun Woo Park,Jae Sung Lee,Gi Jeong Cheon,Gi Jeong Cheon,Jae Gol Choe +8 more
TL;DR: Quantitative parameters using FP-CIT PET template-based method correlated well with those using laborious manual method with excellent concordance, suggesting that PET- based method can provide objective and quantitative parameters quickly and easily as a feasible analysis in place of conventional method.
Journal ArticleDOI
Development of a new precursor-minimizing base control method and its application for the automated synthesis and SPE purification of [(18) F]fluoromisonidazole ([(18) F]FMISO).
TL;DR: The goal of the current study was to develop a new method for synthesizing radiopharmaceuticals that permits the fine control of base concentrations while minimizing adverse events.
Journal ArticleDOI
A practical synthesis of [18F]FtRGD: an angiogenesis biomarker for PET†
TL;DR: The practical use of the nucleophilic detagging and fluorous solid-phase extraction method for the preparation of the 2-[(18) F]fluoroethyl-triazolyl conjugated c(RGDyK) peptide proved valuable for preclinical positron emission tomography imaging of integrin expression.
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Journal ArticleDOI
A new class of SN2 reactions catalyzed by protic solvents: Facile fluorination for isotopic labeling of diagnostic molecules.
Dong Wook Kim,Doo-Sik Ahn,Young-Ho Oh,Sungyul Lee,Hee Seup Kil,Seung Jun Oh,Sang Ju Lee,Jae Seung Kim,Jin-Sook Ryu,Dae Hyuk Moon,Dae Yoon Chi +10 more
TL;DR: This work introduces a remarkable effect of using tertiary alcohols as a reaction medium for nucleophilic fluorination with alkali metal fluorides, greatly increasing the rate of the nucleophile fluorination and reducing formation of byproducts compared with conventional methods using dipolar aprotic solvents.
Journal Article
Dopamine Transporter Imaging with Fluorine-18-FPCIT and PET
Ken Kazumata,Vijay Dhawan,Thomas Chaly,Angelo Antonini,Claude Margouleff,Abdelfatihe Belakhlef,John L. Neumeyer,David Eidelberg +7 more
TL;DR: FPCIT/PET demonstrated age-related decline in dopamine transporter binding in normal subjects as well as significant reductions in patients with idiopathic Parkinson's disease, which correlates with the disease severity.
Journal ArticleDOI
Parametric mapping of [18F]FPCIT binding in early stage Parkinson's disease: A PET study
Yilong Ma,Yilong Ma,Vijay Dhawan,Marc J. Mentis,Thomas Chaly,Phoebe G. Spetsieris,David Eidelberg +6 more
TL;DR: The results suggest that SPM analysis of [18F]FPCIT PET data can be used to quantify and map abnormalities in DAT activity within the human striatum and provides a useful tool to track the onset and progression of PD at its earliest stages.
Journal ArticleDOI
Radiosynthesis of [18F] N-3-fluoropropyl-2-β-carbomethoxy-3-β-(4-iodophenyl) nortropane and the first human study with positron emission tomography
Thomas Chaly,Vijay Dhawan,Ken Kazumata,Angelo Antonini,Claude Margouleff,J.Robert Dahl,Abdelfatihe Belakhlef,Donald Margouleff,Archie Yee,Shaoyin Wang,Gilles Tamagnan,John L. Neumeyer,David Eidelberg +12 more
TL;DR: A procedure for the routine preparation of [18F]FP-CIT has been developed as mentioned in this paper, which is achieved by preparative HPLC using phenethyl column without decomposition or epimerization.
Journal ArticleDOI
[18F]β-CIT-FP is superior to [11C]β-CIT-FP for quantitation of the dopamine transporter
TL;DR: The absence of measurable lipophilic labelled metabolites and the occurrence of transient equilibrium within the time of the PET measurement indicate that [18F] beta-CIT-FP is superior to [11C]beta-Cit-FP as a PET radioligand for quantification of the dopamine transporter in the human brain.