Journal ArticleDOI
New ligands double the scope of the catalytic asymmetric dihydroxylation of olefins
K. Barry Sharpless,Willi Amberg,Matthias Beller,Hou Chen,Jens Hartung,Yasuhiro Kawanami,Doris Lubben,Eric Manoury,Yasukazu Ogino,Tomoyuki Shibata,Tatsuzo Ukita +10 more
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TLDR
Improved ligands render terminal olefins good substrates for the osmium-catalyzed asymmetric dihydroxylation (ADH) process as discussed by the authors.Abstract:
Improved ligands render terminal olefins good substrates for the osmium-catalyzed asymmetric dihydroxylation (ADH) process, and the amounts of chiral ligand and osmium catalyst required diminish dramaticallyread more
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Book ChapterDOI
9.29 – Enantioselective Synthesis
TL;DR: In this article, the main part of the contribution consists of the presentation of the results obtained by different authors on the computational study of enantioselective catalysis, which have an important practical impact, but the main reason for their selection has been the diversity of problems and methods.
Patent
Ligands chiraux heterocycliques et procede de dihydroxylation asymetrique et catalytique d'olefines
K. Barry Sharpless,Matthias Beller,Brent K. Blackburn,Yasahiro Kawanami,Hoi-Lun Kwong,Yasukazu Ogino,Toinoyuki Shibata,Tatsuzo Ukita,Lisa Wang +8 more
TL;DR: On decrit des procedes d'addition sur une olefine, consistant a effectuer une catalyse par osmium as mentioned in this paper, le procede de dihydroxylation asymetrique de la presente invention, une ollfine, un ligand chiral, un solvant organique, de l'eau, un oxydant, and un compose contenant of l'osmium sont combines.
Journal ArticleDOI
Sharpless Asymmetric Dihydroxylation: An Impressive Gadget for the Synthesis of Natural Products: A Review
Aqsa Mushtaq,Ameer Fawad Zahoor,Muhammad Bilal,Syed Makhdoom Hussain,Muhammad Irfan,Rabia Akhtar,Alibay Irfan,Katarzyna Kotwica-Mojzych,Mariusz Mojzych +8 more
TL;DR: Sharpless asymmetric dihydroxylation is an important reaction in the enantioselective synthesis of chiral vicinal diols that involves the treatment of alkene with osmium tetroxide along with optically active quinine ligand as discussed by the authors .
References
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Journal ArticleDOI
Nuclear magnetic resonance enantiomer regents. Configurational correlations via nuclear magnetic resonance chemical shifts of diastereomeric mandelate, O-methylmandelate, and .alpha.-methoxy-.alpha.-trifluoromethylphenylacetate (MTPA) esters
James A. Dale,Harry S. Mosher +1 more
PatentDOI
First practical method for asymmetric epoxidation
Tsutomu Katsuki,K. B. Sharpless +1 more
TL;DR: In this article, a metal alkoxide is used as a catalyst, where the metal has a coordination number of at least four, and at least one, usually two, of the alkoxide groups bonded to the metal are bonded to asymmetric carbon atoms.
Journal ArticleDOI
Asymmetric dihydroxylation via ligand-accelerated catalysis
TL;DR: Dihydroxylation asymetrique de composes ethyleniques du type styrene, vinylcyclohexane, hexene-3 en les glycols correspondants as mentioned in this paper.
Journal ArticleDOI
Asymmetric induction in the reaction of osmium tetroxide with olefins
Journal ArticleDOI
An improved synthesis of the taxol side chain and of RP 56976
TL;DR: In this paper, the methode presentee se fait au depart de phenyl-3 dihydroxy-2,3 propionate de methyle via epoxydation, et d'azoture de sodium.