Journal ArticleDOI
Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis
David S. Celermajer,Keld E. Sørensen,V.M. Gooch,David Spiegelhalter,Owen Miller,Ian D. Sullivan,J.K. Lloyd,John E. Deanfield +7 more
TLDR
Endothelial dysfunction is present in children and adults with risk factors for atherosclerosis, such as smoking and hypercholesterolaemia, before anatomical evidence of plaque formation in the arteries studied, suggesting this may be an important early event in atherogenesis.About:
This article is published in The Lancet.The article was published on 1992-11-07. It has received 4662 citations till now. The article focuses on the topics: Endothelial dysfunction & Coronary artery disease.read more
Citations
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The L-Arginine-Nitric Oxide Pathway
Salvador Moncada,Annie Higgs +1 more
TL;DR: The discovery that mammalian cells generate nitric oxide, a gas previously considered to be merely an atmospheric pollutant, is providing important information about many biologic processes.
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Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: A report of the International Brachial Artery Reactivity Task Force
Mary C. Corretti,Todd J. Anderson,Emelia J. Benjamin,David S. Celermajer,Francois Charbonneau,Mark A. Creager,John E. Deanfield,Helmut Drexler,Marie Gerhard-Herman,David M. Herrington,Patrick Vallance,Joseph A. Vita,Robert A. Vogel +12 more
TL;DR: State-of-the-art information is presented and insights are provided into the strengths and limitations of high-resolution ultrasonography of the brachial artery to evaluate vasomotor function, with guidelines for its research application in the study of endothelial physiology.
Journal ArticleDOI
Coronary Plaque Disruption
TL;DR: This review will explore potential mechanisms responsible for the sudden conversion of a stable atherosclerotic plaque to an unstable and life-threatening atherothrombotic lesion—an event known as plaque fissuring, rupture, or disruption.
Journal ArticleDOI
Multi-Ethnic Study of Atherosclerosis: Objectives and Design
Diane E. Bild,David A. Bluemke,Gregory L. Burke,Robert Detrano,Ana V. Diez Roux,Aaron R. Folsom,Philip Greenland,David R. JacobsJr.,Richard A. Kronmal,Kiang Liu,Jennifer C. Nelson,Daniel H. O'Leary,Mohammed F. Saad,Steven Shea,Moyses Szklo,Russell P. Tracy +15 more
TL;DR: The Multi-Ethnic Study of Atherosclerosis was initiated in July 2000 to investigate the prevalence, correlates, and progression of subclinical cardiovascular disease (CVD) in a population-based sample of 6,500 men and women aged 45-84 years for identification and characterization of CVD events.
Journal ArticleDOI
Photoplethysmography and its application in clinical physiological measurement.
TL;DR: Photoplethysmography is a simple and low-cost optical technique that can be used to detect blood volume changes in the microvascular bed of tissue and is often used non-invasively to make measurements at the skin surface.
References
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Journal ArticleDOI
The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine
TL;DR: It is demonstrated that relaxation of isolated preparations of rabbit thoracic aorta and other blood vessels by ACh requires the presence of endothelial cells, and that ACh, acting on muscarinic receptors of these cells, stimulates release of a substance(s) that causes relaxation of the vascular smooth muscle.
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The Pathogenesis of Atherosclerosis — An Update
TL;DR: A response-to-injury hypothesis of atherogenesis proposes that "injury" to the endothelium is the initiating event in atherosclerosis, and intimal smooth-muscle proliferation as the key event in the development of the advanced lesions of Atherosclerosis.
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Helsinki Heart Study: primary-prevention trial with gemfibrozil in middle-aged men with dyslipidemia. Safety of treatment, changes in risk factors, and incidence of coronary heart disease
Frick Mh,O. Elo,Haapa K,Olli P. Heinonen,P. Heinsalmi,P. Helo,Jussi K. Huttunen,Kaitaniemi P,Koskinen P,Manninen +9 more
TL;DR: Results are in accord with two previous trials with different pharmacologic agents and indicate that modification of lipoprotein levels with gemfibrozil reduces the incidence of coronary heart disease in men with dyslipidemia.
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Paradoxical Vasoconstriction Induced by Acetylcholine in Atherosclerotic Coronary Arteries
P L Ludmer,Andrew P. Selwyn,Thomas Shook,R R Wayne,Gilbert H. Mudge,Robert Alexander,Peter Ganz +6 more
TL;DR: The preliminary findings suggest that the abnormal vascular response to acetylcholine may represent a defect in endothelial vasodilator function, and may be important in the pathogenesis of coronary vasospasm.
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Regression of Coronary Artery Disease as a Result of Intensive Lipid-Lowering Therapy in Men with High Levels of Apolipoprotein B
Greg Brown,John J. Albers,Lloyd D. Fisher,Susan M. Schaefer,Jiin Tarng Lin,Cheryl Kaplan,Xue Qiao Zhao,B. Bisson,Virginia F. Fitzpatrick,Harold T. Dodge +9 more
TL;DR: In men with coronary artery disease who were at high risk for cardiovascular events, intensive lipid-lowering therapy reduced the frequency of progression of coronary lesions, increased the frequencyof regression, and reduced the incidence of cardiovascular events.