Journal ArticleDOI
Novel database for exposure to fragrance ingredients in cosmetics and personal care products.
D. Comiskey,A.M. Api,C. Barratt,E.J. Daly,Graham Ellis,C. McNamara,Cian O’Mahony,Steven H. Robison,Bob Safford,B. Smith,S. Tozer +10 more
TLDR
The data and modelling methods presented show potential as a means of performing ingredient safety assessments for personal care and cosmetics products, and the robustness and ability to estimate aggregate consumer product exposure are presented.About:
This article is published in Regulatory Toxicology and Pharmacology.The article was published on 2015-08-01. It has received 1057 citations till now. The article focuses on the topics: Population.read more
Citations
More filters
Journal ArticleDOI
Criteria for the Research Institute for Fragrance Materials, Inc. (RIFM) safety evaluation process for fragrance ingredients
A.M. Api,D. Belsito,Magnus Bruze,Peter A. Cadby,Peter Calow,Maria Lúcia Zaidan Dagli,W. Dekant,Graham Ellis,Allison D. Fryer,M. Fukayama,Peter Griem,C. Hickey,L Kromidas,J F Lalko,Daniel C. Liebler,Yoshiki Miyachi,Valerie T. Politano,Kevin J. Renskers,G. Ritacco,D. Salvito,Terry W Schultz,I. G. Sipes,B. Smith,D. Vitale,D K Wilcox +24 more
TL;DR: This publication is designed to update the RifM safety assessment process, which follows a series of decision trees, reflecting advances in approaches in risk assessment and new and classical toxicological methodologies employed by RIFM over the past ten years.
Journal ArticleDOI
Use of an aggregate exposure model to estimate consumer exposure to fragrance ingredients in personal care and cosmetic products
Bob Safford,A.M. Api,C. Barratt,D. Comiskey,E.J. Daly,Graham Ellis,C. McNamara,Cian O’Mahony,Steven H. Robison,B. Smith,Russell S. Thomas,S. Tozer +11 more
TL;DR: A newly developed probabilistic model, the Creme RIFM model, is used to estimate aggregate exposure to fragrance ingredients using the example of 2-phenylethanol (PEA) to demonstrate the utility of the model in determining systemic and dermal exposure to fragrances from individual products, and aggregate exposure.
Journal ArticleDOI
Application of the expanded Creme RIFM consumer exposure model to fragrance ingredients in cosmetic, personal care and air care products.
Bob Safford,A.M. Api,C. Barratt,D. Comiskey,Graham Ellis,C. McNamara,Cian O’Mahony,Steven H. Robison,Jane Rose,B. Smith,S. Tozer +10 more
TL;DR: The Creme RIFM model offers a very comprehensive and powerful tool for estimating aggregate exposure to fragrance ingredients, suggesting that deterministic models overestimate exposure by 11.5–25 fold.
Journal ArticleDOI
Integrating habits and practices data for soaps, cosmetics and air care products into an existing aggregate exposure model
D. Comiskey,A.M. Api,C. Barrett,Graham Ellis,C. McNamara,Cian O’Mahony,Steven H. Robison,Jane Rose,Bob Safford,B. Smith,S. Tozer +10 more
TL;DR: The development of Phase 2 Creme RIFM model is described by expanding the previously developed Phase 1 model to include an additional six product types, which covers a broader range of product categories and includes all relevant routes of exposure.
Journal ArticleDOI
Coupled near-field and far-field exposure assessment framework for chemicals in consumer products
TL;DR: A flexible mass balance-based assessment frameworkStructuring multimedia chemical transfers in a matrix of direct inter-compartmental transfer fractions helps understand the contribution of individual pathways to overall human exposure in various product application contexts to inform decisions in different science-policy fields for which exposure quantification is relevant.
References
More filters
Journal Article
A formula to estimate the approximate surface area if height and weight be known. 1916.
Du Bois D,Du Bois Ef +1 more
Journal ArticleDOI
Clinical calorimetry: tenth paper a formula to estimate the approximate surface area if height and weight be known
TL;DR: Means has found that the range of normal variation from the average is smaller and the apparent depression of metabolism in obesity is much less marked when the linear formula, instead of Meeh's formula, is used to determine surface area.
Journal Article
A formula to estimate the approximate surface area if height and weight be known
Journal ArticleDOI
Use of an aggregate exposure model to estimate consumer exposure to fragrance ingredients in personal care and cosmetic products
Bob Safford,A.M. Api,C. Barratt,D. Comiskey,E.J. Daly,Graham Ellis,C. McNamara,Cian O’Mahony,Steven H. Robison,B. Smith,Russell S. Thomas,S. Tozer +11 more
TL;DR: A newly developed probabilistic model, the Creme RIFM model, is used to estimate aggregate exposure to fragrance ingredients using the example of 2-phenylethanol (PEA) to demonstrate the utility of the model in determining systemic and dermal exposure to fragrances from individual products, and aggregate exposure.
Related Papers (5)
Criteria for the Research Institute for Fragrance Materials, Inc. (RIFM) safety evaluation process for fragrance ingredients
A.M. Api,D. Belsito,Magnus Bruze,Peter A. Cadby,Peter Calow,Maria Lúcia Zaidan Dagli,W. Dekant,Graham Ellis,Allison D. Fryer,M. Fukayama,Peter Griem,C. Hickey,L Kromidas,J F Lalko,Daniel C. Liebler,Yoshiki Miyachi,Valerie T. Politano,Kevin J. Renskers,G. Ritacco,D. Salvito,Terry W Schultz,I. G. Sipes,B. Smith,D. Vitale,D K Wilcox +24 more