Nutritional support and growth in thalassaemia major.
George J. Fuchs,Prasong Tienboon,Mohammad A. Khaled,S Nimsakul,S Linpisarn,Abu Syed Golam Faruque,Y Yutrabootr,Marianne DeWier,Robert M. Suskind +8 more
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TLDR
It can be concluded that nutritional stunting as the result of reduced nutrient intake is an important cause of growth failure in young children with thalassaemia and is responsive to nutritional support.Abstract:
Twelve thalassaemic children under 3 years of age received intensive nutritional support for one month and were discharged on a prescribed diet of locally available foods. Anthropometry, bioelectrical impedance analysis and dietary intake were longitudinally assessed. Mean energy intake was 20% greater than the recommended daily allowance during nutritional supplementation as compared with below the recommended daily allowance before and after the period of nutritional support. Weight, but not height, significantly increased during the support period and was due to increases in both fat free mass and fat mass. Body weight, fat free mass and fat mass declined in line with the reduced intake upon return home; however, height velocity accelerated and exceeded normal through the fourth month before resuming a below normal rate. It can be concluded that (1) nutritional stunting as the result of reduced nutrient intake is an important cause of growth failure in young children with thalassaemia and is responsive to nutritional support, (2) the deficit in height velocity was due to retarded truncal height growth, and (3) the bioelectrical impedance analysis method is suitable for body composition analysis of thalassaemic children.read more
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Guidelines for the Management of Transfusion Dependent Thalassaemia (TDT)
TL;DR: The third edition of the TIF guidelines was published by Musallam et al. as mentioned in this paper and includes updated information on new approaches for more effective, safe and less laborious treatment, and an overview of the progress achieved to date towards a total cure using methods such as gene therapy and stem cell transplantation.
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Guidelines for the Standard Monitoring of Patients With Thalassemia: Report of the Thalassemia Longitudinal Cohort.
Venée N. Tubman,Ellen B. Fung,Maria G. Vogiatzi,Alexis A. Thompson,Zora R. Rogers,Ellis J. Neufeld,Janet L. Kwiatkowski +6 more
TL;DR: This review reports on the experience of the Thalassemia Longitudinal Cohort and reviews available literature to establish guidelines for the management of patients with thalasemia.
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Growth hormone (GH) deficiency in patients with β-thalassemia major and the efficacy of recombinant GH treatment
TL;DR: Thalassemic patients with GH deficiency can safely increase their growth velocity with recombinant human GH for2 years; however, the effect on final height still needs to be determined.
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Relationship between Chronic Transfusion Therapy and Body Composition in Subjects with Thalassemia
Ellen B. Fung,Yan Xu,Janet L. Kwiatkowski,Maria G. Vogiatzi,Ellis J. Neufeld,Nancy F. Olivieri,Elliott Vichinsky,Patricia J. Giardina +7 more
TL;DR: Optizing physical activity and appropriate use of transfusion therapy may improve growth and bone health in patients who are at-risk for being underweight in patients with thalassemia.
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The effect of high-calorie diet on nutritional parameters of children with β-thalassaemia major
Ashraf T Soliman,Wael El-Matary,Mohamed M.Abdel Fattah,Ibrahim S. Nasr,Rania K. El Alaily,M. Alaa Thabet +5 more
TL;DR: Increased caloric dietary intake increased significantly IGF-I levels in thalassaemic children, accompanied with increased BMI, mid-arm circumference and skin fold thickness, which can be partially corrected by increasing caloric intake.
References
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Journal Article
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