Obesity and the risk and outcome of infection
R Huttunen,J Syrjänen +1 more
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TLDR
Data are controversial and limited as regards the association between Obesity and the risk and outcome of community-acquired infections such as pneumonia, bacteremia and sepsis and obesity and the course of HIV infection.Abstract:
The interactions between obesity and infectious diseases have recently received increasing recognition as emerging data have indicated an association between obesity and poor outcome in pandemic H1N1 influenza infection. Obesity is an established risk factor for surgical-site infections, nosocomial infections, periodontitis and skin infections. Several studies indicate that acute pancreatitis is more severe in the obese. Data are controversial and limited as regards the association between obesity and the risk and outcome of community-acquired infections such as pneumonia, bacteremia and sepsis and obesity and the course of HIV infection. As the cause-effect relationship between obesity and infection remains obscure in many infectious diseases, further studies are warranted. The consequences of obesity may have substantial effects on the global burden of infectious diseases.read more
Citations
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Journal ArticleDOI
The Epidemiology of Obesity: A Big Picture
Adela Hruby,Frank B. Hu +1 more
TL;DR: The extent of the obesity epidemic, its risk factors—known and novel—, sequelae, and economic impact across the globe are discussed.
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High Prevalence of Obesity in Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) Requiring Invasive Mechanical Ventilation.
Arthur Simonnet,Mikael Chetboun,Julien Poissy,Violeta Raverdy,Jerome Noulette,Alain Duhamel,Julien Labreuche,Daniel Mathieu,François Pattou,Mercé Jourdain +9 more
TL;DR: The COVID‐19 pandemic is rapidly spreading worldwide, notably in Europe and North America where obesity is highly prevalent and the relation between obesity and severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) has not been fully documented.
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Individuals with obesity and COVID-19: A global perspective on the epidemiology and biological relationships.
Barry M. Popkin,Barry M. Popkin,Shufa Du,William R. Green,Melinda A. Beck,Taghred Algaith,Christopher H. Herbst,Reem Alsukait,Reem Alsukait,Mohammed Alluhidan,Nahar Alazemi,Meera Shekar +11 more
TL;DR: Mechanistic pathways for individuals with obesity are presented in depth for factors linked with COVID‐19 risk, severity and their potential for diminished therapeutic and prophylactic treatments among these individuals.
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Immune Dysfunction as a Cause and Consequence of Malnutrition
TL;DR: Focusing on childhood undernutrition, this review summarizes key recent studies from experimental animals, in vitro models, and human cohorts, and proposes that immune dysfunction is both a cause and a consequence of malnutrition.
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Predicting Mortality Due to SARS-CoV-2: A Mechanistic Score Relating Obesity and Diabetes to COVID-19 Outcomes in Mexico.
Omar Yaxmehen Bello-Chavolla,Jessica Paola Bahena-López,Neftali Eduardo Antonio-Villa,Arsenio Vargas-Vázquez,Armando González-Díaz,Alejandro Márquez-Salinas,Carlos A Fermín-Martínez,J. Jesús Naveja,Carlos A. Aguilar-Salinas +8 more
TL;DR: A mechanistic approach to evaluate risk for complications and lethality attributable to COVID-19 considering the effect of obesity and diabetes in Mexico is proposed and offers a clinical tool for quick determination of high-risk susceptibility patients in a first contact scenario.
References
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Obesity : Preventing and managing the global epidemic
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Journal ArticleDOI
Hepatitis C virus infection and diabetes: direct involvement of the virus in the development of insulin resistance
Yoshizumi Shintani,Hajime Fujie,Hideyuki Miyoshi,Takeya Tsutsumi,Kazuhisa Tsukamoto,Satoshi Kimura,Kyoji Moriya,Kazuhiko Koike +7 more
TL;DR: The ability of insulin to lower the plasma glucose level in the HCV transgenic mice was impaired, as observed in chronic hepatitis C patients, providing a direct experimental evidence for the contribution of HCV in the development of insulin resistance in human HCV infection, which finally leads to theDevelopment of type 2 diabetes.
Journal ArticleDOI
Obesity and infection
TL;DR: It is suggested that obese people are more likely than people of normal weight to develop infections of various types including postoperative infections and other nosocomial infections, as well to develop serious complications of common infections.
Journal ArticleDOI
Obesity prevalence from a European perspective: a systematic review
Anne Berghöfer,Tobias Pischon,Thomas Reinhold,Caroline M. Apovian,Arya M. Sharma,Stefan N. Willich +5 more
TL;DR: It is observed that obesity has reached epidemic proportions in Europe, with prevalence rates in Central, Eastern, and Southern Europe being higher than those in Western and Northern Europe.