Occupational exposure and risk of colon cancer: a nationwide registry study with emphasis on occupational exposure to zoonotic gastrointestinal pathogens.
TLDR
In this paper, the authors performed a nationwide registry study to assess potential associations between occupation (history) and colon cancer, including also those occupations with known increased exposure to gastrointestinal pathogens like Salmonella.Abstract:
Objectives While colon cancer (CC) risk is associated with several lifestyle-related factors, including physical inactivity, smoking and diet, the contribution of occupation to CC morbidity remains largely unclear. Growing evidence indicates that gastrointestinal infections like salmonellosis could contribute to CC development. We performed a nationwide registry study to assess potential associations between occupation (history) and CC, including also those occupations with known increased exposure to gastrointestinal pathogens like Salmonella. Methods Person-level occupational data for all residents in The Netherlands were linked to CC diagnosis data. Differences in the incidence of (overall, proximal and distal) CC among occupational sectors and risk groups were tested for significance by calculating standardised incidence ratios (SIRs) with 95% CIs using the general population as reference group. Effects of gender, age, exposure duration and latency were also assessed. Results Significant differences in CC incidence were observed only for a few occupational sectors, including the manufacturing of rubber and plastics, machinery and leather, the printing sector and the information service sector (SIRs 1.06-1.88). No elevated risk of CC was observed among people with increased salmonellosis risk through occupational exposure to live animals, manure or among those working in the sale of animal-derived food products (SIRs 0.93-0.95, 0.81-0.95 and 0.93-1.09 for overall, proximal and distal CC, respectively). Conclusions The results of this study suggest that occupation in itself provides a relatively small contribution to CC incidence. This is consistent with previous studies where a similar degree of variation in risk estimates was observed. The lack of an association with the high-risk occupations for salmonellosis might be due to higher levels of physical activity, a known protective factor for CC and other diseases, of people working in the agricultural sector, which might outweigh the potential Salmonella-associated risk of CC.read more
Citations
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Survival Nomogram for Metastasis Colon Cancer Patients Based on SEER Database
TL;DR: A prediction model for the 1, 3, and 5-year survival rates of metastatic colon cancer patients was developed by analyzing important risk factors for the prognosis of mCC patients based on the SEER database and had an excellent predictive accuracy.
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Significant Rise of Colorectal Cancer Incidence in Younger Adults and Strong Determinants: 30 Years Longitudinal Differences between under and over 50s
Dimitra Sifaki-Pistolla,Viktoria Poimenaki,Ilektra Fotopoulou,Emmanouil Saloustros,Dimitris Mavroudis,L. Vamvakas,Christos Lionis +6 more
TL;DR: There is a clear indication that starting CRC screening at an earlier age may be essential, and an increased incidence in young adults <50 in a European population with low cancer incidence in the past and a worrisome prediction for the near future is confirmed.
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Biofeedback therapy combined with Baduanjin on quality of life and gastrointestinal hormone level in patients with colorectal cancer
TL;DR: On the basis of routine nursing care, patients with CRC combined with biofeedback therapy and Baduanjin exercise can improve the quality of life of patients with colorectal cancer and the efficacy of gastrointestinal hormone levels.
References
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Kristina Kjærheim,Tor Haldorsen,Elsebeth Lynge,Jan Ivar Martinsen,Eero Pukkala,Elisabete Weiderpass,Tom Kristian Grimsrud +6 more
TL;DR: Adjustment for the latent indicators of alcohol and tobacco consumption changed risk estimates for several occupations, gave a less confounded description of risk, and may guide in the identification of true risk factors.
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Occupational risk of salmonellosis and campylobacteriosis: a nationwide population-based registry study
TL;DR: Significant differences in reported salmonellosis and campylobacteriosis incidence exist among occupational sectors, with the highest incidence in those persons occupationally exposed to live animals.
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