Journal ArticleDOI
On the regulation of estrogen production by cortisol and ACTH in human pregnancy at term. Memorial Foundation award thesis.
Hans H. Simmer,Dan Tulchinsky,Ernest M. Gold,Marjorie Frankland,Margaret Greipel,Anita S. Gold +5 more
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TLDR
The data further support the hypothesis that ACTH is a regulating hormone for the fetal adrenal, although no evidence was obtained to substantiate transfer of ACTH from mother to fetus.About:
This article is published in American Journal of Obstetrics and Gynecology.The article was published on 1974-06-01. It has received 86 citations till now. The article focuses on the topics: Estrone & Estriol.read more
Citations
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Journal ArticleDOI
Endocrine control of parturition
TL;DR: This chapter aims to bring together some of the abovementioned theories to show that, for example, the role of the fetus in the initiation of parturition and the concept of progesterone withdrawal may be part of the same mechanism.
Journal ArticleDOI
Placental steroid hormone biosynthesis in primate pregnancy.
TL;DR: The basic mechanisms underlying regulation of steroidogenesis within the fetoplacental unit during primate pregnancy appear similar, in important ways, to those of widely used laboratory animals, such as the rat and rabbit.
Journal ArticleDOI
Possible placental origin of ACTH in normal human pregnancy.
TL;DR: It is reported that maternal ACTH levels increase progressively throughout pregnancy, that urinary free cortisol levels are raised and show resistance to suppression by dexamethasone and evidence is presented suggesting that ACTH may be produced by the placenta.
Journal ArticleDOI
Elevated free cortisol index in pregnancy: Possible regulatory mechanisms
W.E. Nolten,P.A. Rueckert +1 more
TL;DR: Persistence of normal circadian rhythmicity in spite of a continuously elevated FFI and resistance to dexamethasone suppression suggest control of cortisol secretion by normal regulatory mechanisms in pregnancy with resetting of the maternal feedback mechanisms to higher levels.
Journal ArticleDOI
Endocrine activation mimics the adverse effects of prenatal stress on the neuromotor development of the infant primate.
TL;DR: Findings indicate that a delimited period of endocrine activation during pregnancy can have an adverse effect on infant neurobehavioral development, like that of prenatal stress.
References
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Journal ArticleDOI
Some Studies of the Protein-Binding of Steroids and Their Application to the Routine Micro and Ultramicro Measurement of Various Steroids in Body Fluids by Competitive Protein-Binding Radioassay
TL;DR: A 100-fold increase in sensitivity has now been achieved by using tritiated steroids in place of 14C-labeled steroids, by utilizing the CBG's of species other than man, and by using adsorption in Place of dialysis or gel filtration.
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Radioimmunoassay of ACTH in plasma
TL;DR: Marked elevations in plasma ACTH were observed in patients with adrenal insufficiency off steroid therapy, in Cushing's disease after adrenalectomy even in the presence of persistent hypercortisolemia, and in some untreated patients with Cushed's disease.
Journal ArticleDOI
The metabolic clearance rate, blood production, interconversion and transplacental passage of cortisol and cortisone in pregnancy near term.
Inese Z. Beitins,Francis Bayard,Isadore G. Ances,A. Avinoam Kowarski,Claude J. Migeon,Claude J. Migeon +5 more
TL;DR: The maternal contribution to the fetal cortisol and cortisone concentration was calculated and it was estimated that all the BP (E) for the subjects studied arose from BP (F), which suggested that, within the limits of error of the methods used, there was no E secretion.
Journal ArticleDOI
The transplacental passage of prednisone and prednisolone in pregnancy near term
Inese Z. Beitins,Inese Z. Beitins,Francis Bayard,Francis Bayard,Isadore G. Ances,Isadore G. Ances,A. Avinoam Kowarski,A. Avinoam Kowarski,Claude J. Migeon,Claude J. Migeon +9 more
TL;DR: The transplacental passage of prednisone and prednisolone was studied in late pregnancy during a constant infusion of the radioactive steroids to mothers at the time of elective cesarean section and it was found that irrespective of whether 3 H-prednisone or 3 H -prednisolones was infused, the concentration of 3H-predisonsolone in the maternal plasma was significantly higher than that of3 H- Prednisone.
Journal ArticleDOI
Radioimmunoassay of Plasma Estriol
Dan Tulchinsky,Guy E. Abraham +1 more
TL;DR: The hemiscuccinates of E3 were coupled to human serum albumin using carbodiimide, and the conjugates were used to immunize four ewes and one of the antisera obtained after 3 months of immunization was used in the assay procedure.
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