Journal ArticleDOI
One-pot, three-component synthesis of a library of spirooxindole-pyrimidines catalyzed by magnetic nanoparticle supported dodecyl benzenesulfonic acid in aqueous media.
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TLDR
Dodecyl benzenesulfonic acid functionalized silica-coated magnetic nanoparticles (γ-Fe2O3@SiO2-DDBSA) were readily prepared and identified as an efficient catalyst for the synthesis of a library of spirooxindole-pyrimidine derivatives by three-component condensation reaction of barbituric acids, isatins and cyclohexane-1,3-diones.Abstract:
Dodecyl benzenesulfonic acid functionalized silica-coated magnetic nanoparticles (γ-Fe2O3@SiO2-DDBSA) were readily prepared and identified as an efficient catalyst for the synthesis of a library of spirooxindole-pyrimidine derivatives by three-component condensation reaction of barbituric acids, isatins and cyclohexane-1,3-diones. The aqueous reaction medium, easy recovery of the catalyst using an external magnet, and high yields make the protocol sustainable and economic.read more
Citations
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Fast-growing field of magnetically recyclable nanocatalysts.
Dong Wang,Didier Astruc +1 more
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Recent advances in the application of deep eutectic solvents as sustainable media as well as catalysts in organic reactions
TL;DR: Deep eutectic solvents (DESs) have become more and more attractive in recent years due to their interesting properties and benefits, such as low cost of components, easy to prepare, tunable physicochemical properties, negligible vapor pressure, non-toxicity, biorenewability and biodegradability as mentioned in this paper.
Journal ArticleDOI
Molecular diversity of spirooxindoles. Synthesis and biological activity
TL;DR: This review focuses on the various strategies for the enantioselective synthesis of spirocyclic oxindoles relying on reports over the past decade and from earlier work.
Journal ArticleDOI
Magnetically recoverable nanoparticles as efficient catalysts for organic transformations in aqueous medium
TL;DR: In this article, the authors focus on the green catalytic processes and summarize recent advances in organic transformations catalyzed by magnetically recoverable catalysts (MRCs) and provide a basic outline of aqueous catalysis based on water-only or water-and-organic solvent cosolvent systems.
Journal ArticleDOI
Meglumine: A novel and efficient catalyst for one-pot, three-component combinatorial synthesis of functionalized 2-amino-4H-pyrans.
TL;DR: An efficient one-pot synthesis of functionalized 2-amino-4H-pyrans by a meglumine-catalyzed three-component reaction has been developed and provides an alternative approach for rapid access to construct a diversity-oriented library of 4H- pyrans.
References
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Pyrrolidinyl-spirooxindole natural products as inspirations for the development of potential therapeutic agents.
TL;DR: The 3,3'-pyrrolidinyl-spirooxindole unit is a privileged heterocyclic motif that forms the core of a large family of alkaloid natural products with strong bioactivity profiles and interesting structural properties.
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Magnetically recoverable nanocatalysts.
TL;DR: This Review concludes with a conclusion that further research is needed into the determinants of infectious disease and the immune system in order to treat these diseases and provide effective treatments.
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Magnetically Separable Nanocatalysts: Bridges between Homogeneous and Heterogeneous Catalysis
TL;DR: The introduction of magnetic nanoparticles in a variety of solid matrices allows the combination of well-known procedures for catalyst heterogenization with techniques for magnetic separation.
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Green chemistry by nano-catalysis
TL;DR: In this article, the authors focus on the use of nano-catalysis for green chemistry development including the strategy of using microwave heating with nanocatalysis in benign aqueous reaction media which offers an extraordinary synergistic effect with greater potential than these three components in isolation.
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Organocatalytic synthesis of spiro[pyrrolidin-3,3'-oxindoles] with high enantiopurity and structural diversity.
TL;DR: The straightforward construction of spirooxindole skeletons with high stereo- and regioselectivity suggests a new avenue to medicinal chemistry and diversity-oriented synthesis.