Journal ArticleDOI
Optimal design: Variation in structure and performance under change of criterion
TLDR
In this paper, the advisability of comparing designs on the basis of several different criteria of goodness is discussed, including A-, D- and E-optimality, as well as one of Box & Draper.Abstract:
SUMMARY The advisability of comparing designs on the basis of several different criteria of goodness is discussed. As an illustration, designs for quadratic regression on a simplex are compared in terms of a family of criteria that includes those of A-, D- and E-optimality, as well as one of Box & Draper. Efficiency robustness under change of region, as well as of criterion, is considered. The dependence of structure of good designs on dimension is determined.read more
Citations
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Journal ArticleDOI
Response surface methodology: 1966–1988
TL;DR: This article reviews the progrrss of RSM in the general areas of experimental design and analysis and indicates how its role has been affected by advanccs in other fields of applied statistics.
Journal ArticleDOI
B-cell lymphomas with concurrent IGH-BCL2 and MYC rearrangements are aggressive neoplasms with clinical and pathologic features distinct from Burkitt lymphoma and diffuse large B-cell lymphoma.
Matija Snuderl,Olga K. Kolman,Yi Bin Chen,Jessie J. Hsu,Adam M. Ackerman,Paola Dal Cin,Judith A. Ferry,Nancy L. Harris,Robert P. Hasserjian,Lawrence R. Zukerberg,Jeremy S. Abramson,Ephraim P. Hochberg,Hang Lee,Alfred Ian Lee,Christiana E. Toomey,Aliyah R. Sohani +15 more
TL;DR: DHL is a high-grade B-cell neoplasm with a poor prognosis, resistance to multiagent chemotherapy, and clinical and pathologic features distinct from other high- grade B- cell neoplasms.
Journal ArticleDOI
Response Surface Methodology--Current Status and Future Directions
TL;DR: This paper is a reflection on where response surface methodology is at this point and what will likely be future directions.
Journal ArticleDOI
Systems biology: experimental design
Clemens Kreutz,Jens Timmer +1 more
TL;DR: In this minireview, the existing approaches concerning this optimization for parameter estimation and model discrimination are summarized and relevant classical aspects of experimental design, such as randomization, replication and confounding, are reviewed.
Journal ArticleDOI
Computer-Aided Design of Experiments for Response Estimation
TL;DR: The authors generalizes Mitchell's DETMAX algorithm to an arbitrary design criterion and describes an efficient implementation for minimizing either the maximum variance or the average variance of the response estimator over the design region.
References
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Journal ArticleDOI
The Equivalence of Two Extremum Problems
J. Kiefer,J. Wolfowitz +1 more
TL;DR: In this article, the authors consider the problem of defining probability measures with finite support, i.e., measures that assign probability one to a set consisting of a finite number of points.
Journal ArticleDOI
Optimum Designs in Regression Problems
J. Kiefer,Jacob Wolfowitz +1 more
TL;DR: In this paper, the authors consider the problem of finding an optimum design of experiments in regression problems, where the desired inference concerns one of the regression coefficients, and illustrative examples will be given in Section 3.
Journal ArticleDOI
General Equivalence Theory for Optimum Designs (Approximate Theory)
TL;DR: For general optimality criteria, this article obtained criteria equivalent to $\Phi$-optimality under various conditions on ''Phi'' and showed that such equivalent criteria are useful for analytic or machine computation of ''phi''-optimum designs.