Journal ArticleDOI
Oral mucosal disease: recurrent aphthous stomatitis.
Crispian Scully,Stephen Porter +1 more
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TLDR
Diagnosis is on clinical grounds alone, and must be differentiated from other causes of recurrent ulceration, particularly Behçet disease - a systemic disorder in which aphthous-like ulcers are associated with genital ulcers, and eye disease (particularly posterior uveitis).Abstract:
Recurrent aphthous stomatitis (RAS; aphthae; canker sores) is common worldwide. Characterised by multiple, recurrent, small, round, or ovoid ulcers with circumscribed margins, erythematous haloes, and yellow or grey floors, it usually presents first in childhood or adolescence. Its aetiology and pathogenesis is not entirely clear, but there is genetic predisposition, with strong associations with interleukin genotypes, and sometimes a family history. Diagnosis is on clinical grounds alone, and must be differentiated from other causes of recurrent ulceration, particularly Behcet disease - a systemic disorder in which aphthous-like ulcers are associated with genital ulceration, and eye disease (particularly posterior uveitis). Management remains unsatisfactory, as topical corticosteroids and most other treatments only reduce the severity of the ulceration, but do not stop recurrence.read more
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Journal ArticleDOI
Treatment of recurrent aphthous stomatitis. A literature review
TL;DR: The results obtained indicate that the management of RAS should be based on identification and control of the possible predisposing factors, with the exclusion of possible underlying systemic causes, and the use of a detailed clinical history along with complementary procedures such as laboratory tests, where required.
Journal ArticleDOI
Etiopathogenesis of Recurrent Aphthous Stomatitis and the Role of Immunologic Aspects: Literature Review
TL;DR: The main etiopathogenetic factors of RAS are presented with a special emphasis on the mechanisms of the immune response modification and the crucial clinical symptoms and types are discussed.
Journal ArticleDOI
Local drug delivery for oral mucosal diseases: challenges and opportunities
Vidya Sankar,Vanessa Hearnden,K Hull,D. Vidovic Juras,Greenberg,Alexander Ross Kerr,Peter B. Lockhart,Lauren L. Patton,Stephen Porter,Martin H. Thornhill +9 more
TL;DR: This review discusses common mucosal diseases such as oral cancer, mucositis, vesiculo-erosive conditions, infections, neuropathic pain and salivary dysfunction, which could benefit from topical delivery systems designed specifically for the oral mucosa, which are capable of sustained release.
Journal ArticleDOI
Clinical presentation and management of mTOR inhibitor-associated stomatitis.
Marcio Augusto de Oliveira,Fabiana Martins,Qian Wang,Stephen T. Sonis,Stephen T. Sonis,George D. Demetri,Suzanne George,James E. Butrynski,Nathaniel S. Treister,Nathaniel S. Treister +9 more
TL;DR: It is demonstrated that local and systemic corticosteroid therapy is an effective approach to managing patients with symptomatic mIAS, a common and potentially dose limiting toxicity associated with the use of mTOR inhibitors in cancer treatment.
Journal ArticleDOI
Clinical Evaluation of Low-Level Laser Treatment for Recurring Aphthous Stomatitis
Thaís Oricchio Fedri de Souza,Marco Antonio Trevizani Martins,Sandra Kalil Bussadori,Kristianne Porta Santos Fernandes,E. Y. Tanji,Raquel Agnelli Mesquita-Ferrari,Manoela Domingues Martins +6 more
TL;DR: The use of LLLT under the conditions administered in the present study demonstrated analgesic and healing effects with regard to RAS.
References
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Journal ArticleDOI
Sweet's syndrome (acute febrile neutrophilic dermatosis)
TL;DR: The essential features of Sweet's syndrome are outlined, including aspects of epidemiology, histology, diagnosis, and management of the condition, which occurs in middle-aged women after a nonspecific infection of the respiratory or gastrointestinal tract.
Journal ArticleDOI
Syndrome of periodic fever, pharyngitis, and aphthous stomatitis.
Gary S. Marshall,Gary S. Marshall,Kathryn M. Edwards,Kathryn M. Edwards,Joseph L. Butler,Joseph L. Butler,Alexander R. Lawton,Alexander R. Lawton +7 more
TL;DR: This syndrome is sporadic and appears to be much more common than cyclic neutropenia, and may be aborted by short courses of prednisone but do not respond to nonsteroidal anti-inflammatory agents.
Journal ArticleDOI
Number VI Recurrent aphthous stomatitis
TL;DR: Treatment of RAS remains unsatisfactory, as most therapies only reduce the severity of the ulceration and do not stop recurrence, but drugs, especially non-steroidal anti-inflammatory drugs and nicorandil can often control RAS.
Journal ArticleDOI
The diagnosis and management of recurrent aphthous stomatitis: a consensus approach.
TL;DR: A review of the etiopathogenesis, diagnosis and management of recurrent aphthous stomatitis in a primary care setting is presented in this article, where topical corticosteroids remain the mainstay for therapy, while a number of other immunomodulatory modalities now are available.