Journal ArticleDOI
Organocatalytic 1,3-dipolar cycloaddition reactions of ketones and azides with water as a solvent
TLDR
In this paper, an enamine catalyzed strategy was proposed to fully promote a 1,3-dipolar cycloaddition to access a vast pool of substituted 1,2,3 triazoles with water as the only solvent.About:
This article is published in Green Chemistry.The article was published on 2013-08-16. It has received 106 citations till now. The article focuses on the topics: Cycloaddition & 1,3-Dipolar cycloaddition.read more
Citations
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Journal ArticleDOI
Beyond click chemistry - supramolecular interactions of 1,2,3-triazoles.
TL;DR: The intention of this review is to provide a detailed analysis of the various supramolecular interactions of triazoles in comparison to established functional units, which may serve as guidelines for further applications.
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Recent advances in catalysis in micellar media
TL;DR: In this paper, the development of catalytic systems in water in the presence of micelles obtained by addition of surfactants, focusing on the effects of these simple, economic, and green reaction media on important aspects like recyclability, activity, product and substrate selectivity.
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An Organocatalytic Azide–Aldehyde [3+2] Cycloaddition: High‐Yielding Regioselective Synthesis of 1,4‐Disubstituted 1,2,3‐Triazoles
TL;DR: The organo-click reaction is characterized by a high rate and regioselectivity, mild reaction conditions, easily available substrates with simple operation, and excellent yields with a broad spectrum of substrates.
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A Metal‐Free Three‐Component Reaction for the Regioselective Synthesis of 1,4,5‐Trisubstituted 1,2,3‐Triazoles
TL;DR: A metal-free three-component reaction to synthesize 1,4,5-trisubstituted 1,2,3-triazoles from readily available building blocks, such as aldehydes, nitroalkanes, and organic azides, is described, and the products are obtained with high yield and regioselectivity.
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Organocatalytic routes toward substituted 1,2,3-triazoles
TL;DR: The present feature article describes the different organocatalytic routes for the synthesis of substituted 1,2,3-triazoles and the advantages and disadvantages of each method are described with relevant examples.
References
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Cu-catalyzed azide-alkyne cycloaddition.
TL;DR: The basis for the unique properties and rate enhancement for triazole formation under Cu(1) catalysis should be found in the high ∆G of the reaction in combination with the low character of polarity of the dipole of the noncatalyzed thermal reaction, which leads to a considerable activation barrier.
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Organic Reactions in Aqueous Media with a Focus on Carbon−Carbon Bond Formations: A Decade Update
TL;DR: Reaction of R,â-Unsaturated Carbonyl Compounds 3127: Reaction of R-UnSaturated Carbonies 3127 7.1.6.
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Organic chemistry in water
TL;DR: Water has emerged as a versatile solvent for organic chemistry in recent years and gives completely new reactivity, including pericyclic reactions, reactions of carbanion equivalent, and reactions of carbocation equivalent.
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The art and practice of structure-based drug design: a molecular modeling perspective.
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Water: Nature’s Reaction Enforcer—Comparative Effects for Organic Synthesis “In-Water” and “On-Water”
TL;DR: This work presents a meta-analysis of cycloaddition, which aims to determine the carrier and removal status of H2O through a number of mechanisms, including “catalyzed” and “pericyclic” reactions.