Journal ArticleDOI
Over-expression of rexA nullifies T4rII exclusion in Escherichia coli K(λ) lysogens
Roderick A. Slavcev,Sidney Hayes +1 more
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TLDR
Dosage and relative cellular levels of RexA and RexB proteins encoded by the rexA–rexB genes of a λ prophage are important for the Rex+ phenotype, which was nullified when greater RexA or RexB was provided than was necessary for the complementation of a rex a– or a reXB– prophages.Abstract:
Dosage and relative cellular levels of RexA and RexB proteins encoded by the rexA–rexB genes of a λ prophage are important for the Rex+ phenotype, which was nullified when greater RexA or RexB was provided than was necessary for the complementation of a rexA– or a rexB– prophage.Key words: bacteriophage lambda (λ), T4rII exclusion (Rex) phenotype, lambda pM–cI–rexA–rexB–timm operon.read more
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Book ChapterDOI
Bacteriophage host range and bacterial resistance.
Paul Hyman,Stephen T. Abedon +1 more
TL;DR: How phage host range can (and should) be defined plus claims of host ranges spanning multiple bacterial genera are summarized plus bacterial mechanisms of phage resistance are reviewed.
Journal ArticleDOI
Polarity within pM and pE promoted phage lambda cI-rexA-rexB transcription and its suppression.
Sidney Hayes,Roderick A. Slavcev +1 more
TL;DR: Strong suppression of the conditional Rex[Ts] phenotype was imparted by ssrA and clpP (polar for clpX) null mutations, suggesting that RexA or RexB proteins made under conditions of polarity are subject to 10Sa RNA tagging and ClpXP degradation.
Book ChapterDOI
The origin of the bacterial immune response.
TL;DR: This chapter reviews the bacterial strategies that hinder the phage infection as well as the counter-defense mechanisms developed.
Bacteriophage T4 lysis and lysis inhibition: molecular basis of an ancient story
TL;DR: Topological analysis of RI and T showed that antiholin RI inhibits T-mediated lysis by direct interaction with the holin, suggesting RI inhibits Lysis inhibition by interacting with T via RICTD.
References
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Journal ArticleDOI
Fine Structure of a Genetic Region in Bacteriophage
TL;DR: A functionally related region in the genetic material of a bacteriophage that is finely subdivisible by mutation and by genetic recombination is described, which resembles similar cases which have been observed in many organisms, usually designated as "pseudo-alleles."
Journal ArticleDOI
The Rex system of bacteriophage lambda: tolerance and altruistic cell death.
TL;DR: It is suggested that RexB proteins form ion channels that, in response to lytic growth of bacteriophages, depolarize the cytoplasmic membrane and are likely to be a polytopic transmembrane protein.
Journal ArticleDOI
rexB of bacteriophage λ is an anti-cell death gene
Hanna Engelberg-Kulka,Myriam Reches,Sudarsan Narasimhan,Rachel Schoulaker-Schwarz,Yoel Klemes,Einat Aizenman,Gad Glaser +6 more
TL;DR: It is proposed that the λrex operon has an additional function to the well known phenomenon of exclusion of other phages; it can prevent the death of lysogenized cells under conditions of nutrient starvation and may be considered as the “survival operon” of phage λ.
Journal ArticleDOI
The rex genes of bacteriophage lambda can inhibit cell function without phage superinfection
TL;DR: It is proposed that at least some of the exclusion caused by the Rex proteins could be due to a change in their ratio following superinfection.
Journal ArticleDOI
Wild-type bacteriophage T4 is restricted by the lambda rex genes.
TL;DR: The relationship between rex and rII has been found to be quantitative, and plasmid clones of rex have excluded not only rII mutants but T4 wild type and most other bacteriophages as well.
Related Papers (5)
Polarity within pM and pE promoted phage lambda cI-rexA-rexB transcription and its suppression.
Sidney Hayes,Roderick A. Slavcev +1 more