Journal ArticleDOI
Oxidative stress and antioxidants in hypertension-a current review.
Nakshi Sinha,Pradeep Kumar Dabla +1 more
TLDR
The aim of this review is to present a novel focus on the role of oxidative stress in the pathophysiology of hypertension and recent biomarkers which are found to be associated with reactive oxygen species and therole of antioxidants as therapy of hypertension.Abstract:
Free radicals or reactive oxygen species (ROS) are generated by oxygen metabolism which is balanced by the rate of oxidant formation and the rate of oxidant elimination. Oxidative stress is a result of imbalance between the generation of reactive oxygen species (ROS) and the antioxidant defence systems. Hypertension is one of the major risk factors for cardiovascular diseases and is considered as a leading cause of mortality and morbidity. These diseases affect more than 600 million people and it has been estimated that 29% of the world population will be suffering from hypertension by 2025. It has been indicated by experimental evidence that reactive oxygen species (ROS) play an important role in the pathophysiology of hypertension. The vasculature is a rich source of NADPH oxidase which produces most of the reactive oxygen species and plays an important role in renal dysfunction and vascular damage. Recent studies indicate that increased oxidative stress is the important mediator of endothelial injury in the pathology of hypertension associated to increased production of pro oxidants such as superoxideanion hydrogen peroxide, reduced nitric oxide synthesis and decreased bioavailability of antioxidants. Oxidative stress is found to be associated with endothelial dysfunction, inflammation, hypertrophy, apoptosis, cell migration, fibrosis, and angiogenesis in relation to vascular remodelling of hypertension. Results in humans are still less conclusive inspite of data available that involve oxidative stress as a causative factor of essential hypertension. The aim of this review is to present a novel focus on the role of oxidative stress in the pathophysiology of hypertension and recent biomarkers which are found to be associated with reactive oxygen species and the role of antioxidants as therapy of hypertension.read more
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Journal ArticleDOI
Integrated Analysis of miRNA and mRNA Regulation Network in Hypertension.
Feng Liu,Qinghua Li,Li Juan Li +2 more
Peer Review
Chronic Kidney Disease and associated Oxidative Stress with low levels of some important vital indicators
TL;DR: In this paper , a survey aimed to evaluate the situation of oxidative stress in sufferers with chronic kidney disease via measuring some biochemical variables within the serum of 65 wholesome human beings as a control group among the a while of 38-60 years.
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Sodium acetate ameliorates doxorubicin-induced cardiac injury via upregulation of Nrf2/HO-1 signaling and downregulation of NFkB-mediated apoptotic signaling in Wistar rats.
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Fullerene [60] encapsulated water-soluble supramolecular cage for prevention of oxidative stress-induced myocardial injury
Guanzhao Zhang,Hui Fang,Shuting Chang,Renzeng Chen,Lanlan Li,Shuo Zhao,Yamei Liu,Ruyi Sun,Yingjie Zhao,Bo'ao Li +9 more
TL;DR: In this paper , a water-soluble cube-like supramolecular cage was constructed by an engagement of six molecules through a hydrophobic effect in the water, which could perfectly encapsulate one fullerene C60 molecule inside of the cavity and significantly improved the water solubility of the C60 without changing the original structure.
Journal ArticleDOI
Vitamin C modulates adrenaline-augmented gastric injury via cardiac troponin/creatine kinase pathway in Wistar rats.
TL;DR: In this paper , the effect of vitamin C on gastric parameters in myocardial injury in rats was investigated and the results showed that pre-and post-vitamin C treatment reduced (P<0.05) ulcer score, and increased (P <0.5) pepsin activity, mucus weight, and serum vitamin C levels.