Journal ArticleDOI
Oxidative stress and antioxidants in hypertension-a current review.
Nakshi Sinha,Pradeep Kumar Dabla +1 more
TLDR
The aim of this review is to present a novel focus on the role of oxidative stress in the pathophysiology of hypertension and recent biomarkers which are found to be associated with reactive oxygen species and therole of antioxidants as therapy of hypertension.Abstract:
Free radicals or reactive oxygen species (ROS) are generated by oxygen metabolism which is balanced by the rate of oxidant formation and the rate of oxidant elimination. Oxidative stress is a result of imbalance between the generation of reactive oxygen species (ROS) and the antioxidant defence systems. Hypertension is one of the major risk factors for cardiovascular diseases and is considered as a leading cause of mortality and morbidity. These diseases affect more than 600 million people and it has been estimated that 29% of the world population will be suffering from hypertension by 2025. It has been indicated by experimental evidence that reactive oxygen species (ROS) play an important role in the pathophysiology of hypertension. The vasculature is a rich source of NADPH oxidase which produces most of the reactive oxygen species and plays an important role in renal dysfunction and vascular damage. Recent studies indicate that increased oxidative stress is the important mediator of endothelial injury in the pathology of hypertension associated to increased production of pro oxidants such as superoxideanion hydrogen peroxide, reduced nitric oxide synthesis and decreased bioavailability of antioxidants. Oxidative stress is found to be associated with endothelial dysfunction, inflammation, hypertrophy, apoptosis, cell migration, fibrosis, and angiogenesis in relation to vascular remodelling of hypertension. Results in humans are still less conclusive inspite of data available that involve oxidative stress as a causative factor of essential hypertension. The aim of this review is to present a novel focus on the role of oxidative stress in the pathophysiology of hypertension and recent biomarkers which are found to be associated with reactive oxygen species and the role of antioxidants as therapy of hypertension.read more
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Journal ArticleDOI
Age- and Phenotype-Dependent Changes in Circulating MMP-2 and MMP-9 Activities in Normotensive and Hypertensive Rats.
Marta Kollárová,Angelika Puzserova,Peter Balis,Dominika Radosinska,Lubomira Tothova,Monika Bartekova,Monika Bartekova,Miroslav Barancik,Jana Radosinska,Jana Radosinska +9 more
TL;DR: The results of this study suggest that hypertension is accompanied by varying MMP activation during aging, and may indicate that MMP-2 inhibition is therapeutically applicable during the development of hypertension, while in developed, stabilized and uncomplicated hypertension, systemic Mmp-2 and M MP-9 inhibition may not be desirable.
Journal ArticleDOI
Comparison of the antioxidant activity, phytochemical and nutritional contents of two antihypertensive ethnomedicinal plants
I.T. Gbadamosi,A.O. Kalejaye +1 more
TL;DR: It was observed that there was direct relationship between polyphenol content and antioxidant activity of the plants, and there were also significant variations in the chemical components of the two plants.
Journal ArticleDOI
Protective role of hazelnut peptides on oxidative stress injury in human umbilical vein endothelial cells
TL;DR: The results indicate that hazelnut peptides can ensure normal growth of cells by protecting important antioxidant enzyme systems, by enhancing antioxidant defense, and by reducing intracellular reactive oxygen species (ROS) production in HUVECs, indicating that the three antioxidative peptides have a protective effect against Ang II-induced oxidative stress injury.
Journal ArticleDOI
Research Progress of Ferroptosis: A Bibliometrics and Visual Analysis Study.
Jian Xiong,Wenchuan Qi,Jiacheng Liu,Zhenqing Zhang,Ziwen Wang,Jinku Bao,Chuanfang Wu,Fanrong Liang +7 more
TL;DR: In this article, the authors used the literature management software Bibexcel and knowledge graph tool VOSviewer to summarize and analyze the international research trends and hotspots about ferroptosis in recent years.
Journal ArticleDOI
Apelin-36 Protects HT22 Cells Against Oxygen-Glucose Deprivation/Reperfusion-Induced Oxidative Stress and Mitochondrial Dysfunction by Promoting SIRT1-Mediated PINK1/Parkin-Dependent Mitophagy.
TL;DR: In this paper, the effects of Apelin-36 on cerebral ischemia/reperfusion injury-induced neuronal apoptosis in cerebral I/R injury were investigated.