Journal ArticleDOI
Palladium-catalyzed synthesis of 2-substituted indoles
Duane E. Rudisill,John K. Stille +1 more
TLDR
The palladium(0)-catalyzed cross-coupling reaction of alkynylstannanes with 2-bromoanilines or 2-trifloxyanilines results in the formation of 2-alkynylanilines.Abstract:
The palladium(0)-catalyzed cross-coupling reaction of alkynylstannanes with 2-bromoanilines or 2-trifloxyanilines results in the formation of 2-alkynylanilines. The coupling reaction tolerates substituents on the anilines, including ester, ether, chloro, and trifloxy groups. A palladium(II)-catalyzed intramolecular cyclization provides 2-substituted indoles. The cyclization proceeds without the need to reoxidize the metal and is most efficient with aliphatic substituents on the alkynyl terminus.read more
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Journal ArticleDOI
Synthesis and functionalization of indoles through palladium-catalyzed reactions
Sandro Cacchi,Giancarlo Fabrizi +1 more
TL;DR: P palladium-catalyzed synthesis can provide access to fine chemicals, agrochemical and pharmaceutical intermediates, and active ingredients in fewer steps and with less waste than classical.
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