Journal ArticleDOI
Pancreatic pathology in non-insulin dependent diabetes (NIDDM).
Anne Clark,E. J. P. de Koning,Andrew T. Hattersley,Barbara C. Hansen,C.S. Yajnik,Joanna Poulton +5 more
TLDR
Pathological changes in the exocrine and endocrine pancreas in N IDDM results from and contributes to the pathophysiology of insulin secretion in NIDDM.About:
This article is published in Diabetes Research and Clinical Practice.The article was published on 1995-01-01. It has received 52 citations till now. The article focuses on the topics: Maturity onset diabetes of the young & Amyloidosis.read more
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Journal ArticleDOI
Chronic exposure to free fatty acid reduces pancreatic beta cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation.
TL;DR: It is suggested that chronically elevated FFA contribute to beta cell dysfunction in the pathogenesis of NIDDM by significantly increasing the basal rate of insulin secretion and results in a decrease in the beta cell's intracellular stores that cannot be offset by commensurate FFA induction of proinsulin biosynthesis.
Journal ArticleDOI
Abeta amyloid fibrils possess a core structure highly resistant to hydrogen exchange.
TL;DR: The results suggest that it is unlikely that the entire Abeta sequence is involved in H-bonded secondary structure within the amyloid fibril, and further studies using the methods described here should reveal further details of Abeta fibrils structure and assembly.
Journal ArticleDOI
Fibril Structure of Human Islet Amyloid Polypeptide
Sahar Bedrood,Yiyu Li,J. Mario Isas,Balachandra G. Hegde,Ulrich Baxa,Ian S. Haworth,Ralf Langen +6 more
TL;DR: This work developed an approach that combines site-directed spin labeling with continuous wave and pulsed EPR to investigate local secondary structure and to determine the relative orientation of the secondary structure elements with respect to each other.
Journal ArticleDOI
Molecular interaction between type 2 diabetes and Alzheimer's disease through cross-seeding of protein misfolding.
Ines Moreno-Gonzalez,George A. Edwards,Natalia Salvadores,Mohammad Shahnawaz,Rodrigo Diaz-Espinoza,Claudio Soto +5 more
TL;DR: It is observed that addition of IAPP seeds accelerates Aβ aggregation in vitro in a seeding-like manner and the resulting fibrils are composed of both peptides, suggesting that these peptides may directly interact and aggravate the disease.
Journal ArticleDOI
Modifiable Risk Factors for Alzheimer's Disease.
George A. Edwards,Nazaret Gamez,Nazaret Gamez,Gabriel Escobedo,Olivia Calderon,Ines Moreno-Gonzalez,Ines Moreno-Gonzalez +6 more
TL;DR: Modifiable risk factors are discussed and the current literature of how each of these factors interplay into AD development and progression is discussed and if strategically analyzed and treated, could aid in protection against this neurodegenerative disease.