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Christopher J. Rhodes

Researcher at AstraZeneca

Publications -  148
Citations -  20785

Christopher J. Rhodes is an academic researcher from AstraZeneca. The author has contributed to research in topics: Insulin & Kinase. The author has an hindex of 74, co-authored 144 publications receiving 18700 citations. Previous affiliations of Christopher J. Rhodes include Harvard University & University of Texas Southwestern Medical Center.

Papers
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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, +1287 more
- 01 Apr 2012 - 
TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Type 2 Diabetes-a Matter of ß-Cell Life and Death?

Christopher J. Rhodes
- 21 Jan 2005 - 
TL;DR: Evidence supporting the notion that increased β-cell apoptosis is an important factor contributing toβ-cell loss and the onset of type 2 diabetes is discussed.
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Regulation of Endothelial Constitutive Nitric Oxide Synthase Gene Expression in Endothelial Cells and In Vivo A Specific Vascular Action of Insulin

Koji Kuboki, +9 more
- 15 Feb 2000 - 
TL;DR: Insulin can regulate the expression of eNOS gene, mediated by the activation of PI-3 kinase, in endothelial cells and microvessels, and may chronically modulate vascular tone.
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Intracellular signalling. Key enzyme in leptin-induced anorexia.

Kevin D. Niswender, +5 more
- 25 Oct 2001 - 
TL;DR: It is shown that systemic administration of leptin in rats activates the enzyme phosphatidylinositol-3-OH kinase in the hypothalamus and that intracerebro-ventricular infusion of inhibitors of this enzyme prevents leptin-induced anorexia.
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The Hyperglycemia-induced Inflammatory Response in Adipocytes THE ROLE OF REACTIVE OXYGEN SPECIES

Ying Lin, +15 more
- 11 Feb 2005 - 
TL;DR: Analysis of adipocytes exposed to hyperglycemia both in vitro as well as in vivo highlights the importance ROS production in adipocytes and the associated insulin resistance and inflammatory response.