Journal ArticleDOI
Pathological features of classical polyarteritis nodosa: Analysis of 19 autopsy cases
TLDR
On immunohistochemical examination, the cPN group showed high matrix metalloproteinase-1 and tumor necrosis factor-α expressions and decreased smoothelin expression in the vascular wall compared to the control group, which can help to make the pathological diagnosis of cPN.Abstract:
Classical polyarteritis nodosa (cPN) is a rare autoimmune disease featuring systemic inflammation of middle- and small-sized arteries. Because most of autopsy cases underwent clinical treatment, arterial fibrinoid necrosis, which is the most specific finding of cPN, is often obscure. The aim of this study was to seek morphological characteristics of the middle-sized arteries in autopsy cases of cPN, and to identify immunohistochemical markers for the diagnosis of cPN. Nineteen patients who had undergone autopsy with a diagnosis of cPN were enrolled. Twenty-one autopsy cases without cPN were examined as control group. Arterial fibrinoid necrosis in medium-sized arteries was observed in 8/19 autopsy cases. Elastica van Gieson staining showed an increased number of elastic fiber layers (P<0.0001) and greater distances between elastic fiber layers (P<0.0001) in the renal middle-sized arteries of the cPN group. These findings probably reflected the post-inflammatory remodeling process after necrotizing vasculitis. On immunohistochemical examination, the cPN group showed high matrix metalloproteinase-1 and tumor necrosis factor-α expressions and decreased smoothelin expression in the vascular wall compared to the control group. When uncertain or atypical autopsy cases of cPN are examined, these findings can help to make the pathological diagnosis of cPN.read more
Citations
More filters
Journal ArticleDOI
Cholangitis as an initial manifestation of polyarteritis nodosa.
Risa Kanai,Masamoto Nakamura,Kota Tomisato,Tomofumi Fukuhara,Akiyuki Kondo,Shoko Nakamura,Shinobu Matsukawa,Akira Yabutani,Kasen Kobashikawa,Tomokuni Nakayoshi,Nobufumi Uchima,Noritake Kosuge,Naoki Yoshimi +12 more
TL;DR: An autopsy revealed a ruptured hepatic artery aneurysm, which had caused lethal intra-abdominal bleeding and systemic necrotizing vasculitis of small- and medium-sized arteries, and polyarteritis nodosa (PAN) was diagnosed after the autopsy.
Journal ArticleDOI
Sudden death of a child from myocardial infarction due to arteritis of the left coronary trunk
Shirushi Takahashi,Aya Takada,Kazuyuki Saito,Masaaki Hara,Katsumi Yoneyama,Hiroaki Nakanishi,Kei Takahashi,Takuya Moriya,Masato Funayama +8 more
TL;DR: The present case showed no findings suggesting classical polyarteritis nodosa (cPAN) at the acute or scar stage in the other vessels being investigated, and cPAN in childhood is rare compared to KD.
Journal ArticleDOI
Remarks on the Asia Pacific Meeting of Vasculitis and ANCA Workshop 2012
TL;DR: The Asia Pacific international meeting was able to extend insights into Kawasaki disease, Takayasu arteritis, and myeloperoxidase ANCA-associated vasculitis.
References
More filters
Journal ArticleDOI
Nomenclature of systemic vasculitides. Proposal of an international consensus conference
Jc Jennette,Ronald J. Falk,K Andrassy,Pa Bacon,J Churg,J Churg,Wl Gross,Wl Gross,E. C. Hagen,Gs Hoffman,Gg Hunder,Cgm Kallenberg,Rt Mccluskey,Ra Sinico,Ra Sinico,Aj Rees,La Vanes,R Waldherr,Allan Wiik +18 more
TL;DR: The following are some of the conclusions and proposals made at the Chapel Hill Consensus Conference on the Nomenclature of Systemic Vasculitis.
Journal ArticleDOI
Development and validation of a consensus methodology for the classification of the ANCA-associated vasculitides and polyarteritis nodosa for epidemiological studies
Richard A. Watts,SE Lane,Thomas Hanslik,Thomas H. Hauser,Bernhard Hellmich,Wenche Koldingsnes,Alfred Mahr,Mårten Segelmark,Jan Willem Cohen-Tervaert,David Scott +9 more
TL;DR: A stepwise algorithm developed by consensus between a group of doctors interested in the epidemiology of vasculitis successfully categorises patients into a single classification of patients with Wegener’s granulomatosis, microscopic polyangiitis, Churg–Strauss syndrome and PAN into single clinically relevant categories.
Journal ArticleDOI
Wegener's Granulomatosis
TL;DR: A mechanism of hypersensitivity apparently operates in the pathogenesis of Wegener's granulomatosis, with arteritis or uremia dominating the terminal picture in cases so far recognized.
Journal ArticleDOI
The American College of Rheumatology 1990 criteria for the classification of vasculitis. Introduction.
Gene G. Hunder,William P. Arend,William P. Arend,Daniel A. Bloch,Leonard H. Calabrese,Leonard H. Calabrese,Anthony S. Fauci,Anthony S. Fauci,James F. Fries,James F. Fries,Randi Y. Leavitt,Randi Y. Leavitt,J. T. Lie,Robert W. Lightfoot,Robert W. Lightfoot,Alfonse T. Masi,Alfonse T. Masi,Dennis J. McShane,Dennis J. McShane,Beat A. Michel,John A. Mills,John A. Mills,Mary Betty Stevens,Mary Betty Stevens,Stanley L. Wallace,Stanley L. Wallace,Nathan J. Zvaifler,Nathan J. Zvaifler +27 more
Journal ArticleDOI
Illustrated histopathologic classification criteria for selected vasculitis syndromes. American College of Rheumatology Subcommittee on Classification of Vasculitis.
TL;DR: The histopathologic criteria for the diagnosis of 7 selected vasculitis syndromes are described: polyarteritis nodosa, Churg-Strauss syndrome, Wegener's granulomatosis, hypersensitivity Vasculitis, Henoch-Schönlein purpura, giant cell (temporal) arteritis, and Takayasu arteritis.