Pathophysiology of human glaucomatous optic nerve damage: insights from rodent models of glaucoma
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TLDR
Major insights have been gained into ONH and the retinal cellular responses to elevated IOP that, in time, can be applied to the primate model and, ultimately, human glaucoma.About:
This article is published in Experimental Eye Research.The article was published on 2011-08-01 and is currently open access. It has received 112 citations till now. The article focuses on the topics: Optic disk & Optic nerve.read more
Citations
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Journal ArticleDOI
Enhanced depth imaging detects lamina cribrosa thickness differences in normal tension glaucoma and primary open-angle glaucoma.
TL;DR: The EDI mode of the Heidelberg Spectralis SD-OCT detected differences in the lamina cribrosa by glaucoma type, and the laminar thickness was thinner in NTG eyes and inNTG eyes with disc hemorrhage.
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Critical pathogenic events underlying progression of neurodegeneration in glaucoma.
TL;DR: While ganglion cell somatic drop-out is later in progression, some evidence suggests that synaptic and dendritic pruning in the retina may be a more dynamic process, which offers the possibility that intrinsic self-repair pathways counter pathogenic mechanisms to delay as long as possible outright loss of tissue.
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IOP induces upregulation of GFAP and MHC-II and microglia reactivity in mice retina contralateral to experimental glaucoma
Beatriz I. Gallego,Juan J. Salazar,Rosa de Hoz,Blanca Rojas,Ana I. Ramírez,Manuel Salinas-Navarro,Arturo Ortín-Martínez,Francisco J. Valiente-Soriano,Marcelino Avilés-Trigueros,María Paz Villegas-Pérez,Manuel Vidal-Sanz,Alberto Triviño,José Ramírez +12 more
TL;DR: The absence of NF-200+RGCs (sign of RGC degeneration) leads us to postulate that the MHC-II upregulation in contralateral eyes could favor neuroprotection.
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Understanding glaucomatous damage: Anatomical and functional data from ocular hypertensive rodent retinas
Manuel Vidal-Sanz,Manuel Salinas-Navarro,Francisco M. Nadal-Nicolás,Luis Alarcon-Martinez,F Javier Valiente-Soriano,Jaime Miralles de Imperial,Marcelino Avilés-Trigueros,Marta Agudo-Barriuso,María Paz Villegas-Pérez +8 more
TL;DR: The deleterious anatomical and functional effects of ocular hypertension on retinal ganglion cells (RGCs) in adult rodents are discussed and functional and morphological studies show permanent alterations of the inner and outer retinal layers, indicating that further to a crush-like injury of axon bundles in the optic nerve head there may by additional insults to the retina.
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Morphology of Astrocytes in a Glaucomatous Optic Nerve
TL;DR: Confirming results after optic nerve crush, astrocytes in glaucomatous optic nerves had thickened and simplified processes, and reduced spatial coverage, and found evidence of localized sprouting of new processes in early stages of the disease, before detectable changes in ganglion cell number.
References
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The Ocular Hypertension Treatment Study: A Randomized Trial Determines That Topical Ocular Hypotensive Medication Delays or Prevents the Onset of Primary Open-Angle Glaucoma
Michael A. Kass,Dale K. Heuer,Eve J. Higginbotham,Chris A. Johnson,John L. Keltner,J. Philip Miller,Richard K. Parrish,M. Roy Wilson,Mae O. Gordon +8 more
TL;DR: Topical ocular hypotensive medication was effective in delaying or preventing the onset of POAG in individuals with elevated IOP, and clinicians should consider initiating treatment for individuals with ocular hypertension who are at moderate or high risk for developing POAG.
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Reduction of intraocular pressure and glaucoma progression: results from the Early Manifest Glaucoma Trial.
TL;DR: The first adequately powered randomized trial with an untreated control arm to evaluate the effects of IOP reduction in patients with open-angle glaucoma who have elevated and normal IOP showed considerable beneficial effects of treatment that significantly delayed progression.
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The advanced glaucoma intervention study (AGIS): 7. the relationship between control of intraocular pressure and visual field deterioration
Fred Ederer,Ma,Douglas E. Gaasterland,E. Kenneth Sullivan,Allen D. Beck,Bruce E. Prum,Marshall N. Cyrlin,Howard S. Weiss +7 more
TL;DR: In both analyses low intraocular pressure is associated with reduced progression of visual field defect, supporting evidence from earlier studies of a protective role for low intracular pressure in visual field deterioration.
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Optic nerve damage in human glaucoma. II. The site of injury and susceptibility to damage.
TL;DR: Scanning electron microscopic analysis suggests that the structure of the lamina cribrosa is an important determinant of the degree of susceptibility to damage by elevated intraocular pressure.
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