Open Access
Performance standards for antimicrobial susceptibility testing
Reads0
Chats0
TLDR
The supplemental information presented in this document is intended for use with the antimicrobial susceptibility testing procedures published in the following Clinical and Laboratory Standards Institute (CLSI)–approved standards.Abstract:
The supplemental information presented in this document is intended for use with the antimicrobial susceptibility testing procedures published in the following Clinical and Laboratory Standards Institute (CLSI)–approved standards: M02-A12—Performance Standards for Antimicrobial Disk Susceptibility Tests; Approved Standard—Twelfth Edition; M07-A10—Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically; Approved Standard—Tenth Edition; and M11-A8—Methods for Antimicrobial Susceptibility Testing of Anaerobic Bacteria; Approved Standard— Eighth Edition. The standards contain information about both disk (M02) and dilution (M07 and M11) test procedures for aerobic and anaerobic bacteria. Clinicians depend heavily on information from the microbiology laboratory for treatment of their seriously ill patients. The clinical importance of antimicrobial susceptibility test results demands that these tests be performed under optimal conditions and that laboratories have the capability to provide results for the newest antimicrobial agents. The tabular information presented here represents the most current information for drug selection, interpretation, and QC using the procedures standardized in the most current editions of M02, M07, and M11. Users should replace the tables published earlier with these new tables. (Changes in the tables since the previous edition appear in boldface type.) Clinical and Laboratory Standards Institute (CLSI). Performance Standards for Antimicrobial Susceptibility Testing. 26th ed. CLSI supplement M100S (ISBN 1-56238-923-8 [Print]; ISBN 1-56238924-6 [Electronic]). Clinical and Laboratory Standards Institute, 950 West Valley Road, Suite 2500, Wayne, Pennsylvania 19087 USA, 2016. The data in the interpretive tables in this supplement are valid only if the methodologies in M02-A12—Performance Standards for Antimicrobial Disk Susceptibility Tests; Approved Standard—Twelfth Edition; M07-A10—Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically; Approved Standard—Tenth Edition; and M11-A8—Methods for Antimicrobial Susceptibility Testing of Anaerobic Bacteria; Approved Standard— Eighth Edition are followed.read more
Citations
More filters
Journal ArticleDOI
Mutations in blaKPC-3 That Confer Ceftazidime-Avibactam Resistance Encode Novel KPC-3 Variants That Function as Extended-Spectrum β-Lactamases
TL;DR: Using site-directed mutagenesis and transforming vectors into Escherichia coli, it was conclusively demonstrated that mutant blaKPC-3 encoded enzymes that functioned as extended-spectrum β-lactamases; mutations directly conferred higher MICs of ceftazidime-avibactam and decreased theMICs of carbapenems and other β- lactams.
Journal ArticleDOI
Emergence of carbapenem-resistant serotype K1 hypervirulent Klebsiella pneumoniae strains in China
TL;DR: Findings indicate that K1 hvKP is simultaneously hypervirulent, multidrug resistant, and transmissible.
Journal ArticleDOI
High prevalence of nasal MRSA carriage in slaughterhouse workers in contact with live pigs in The Netherlands
B.A.G.L. van Cleef,Els M. Broens,Andreas Voss,X. W. Huijsdens,L. Züchner,B. H. B. Van Benthem,Jan Kluytmans,Mick N. Mulders,A.W. van de Giessen +8 more
TL;DR: A high prevalence of nasal MRSA carriage was found in pig-slaughterhouse workers, and working with live pigs is the most important risk factor.
Journal ArticleDOI
Outbreak of extended-spectrum β-lactamase-producing Klebsiella oxytoca infections associated with contaminated handwashing sinks(1).
Christopher F. Lowe,Barbara M. Willey,Anna O’Shaughnessy,Wayne Lee,Ming Lum,Karen Pike,Cindy Larocque,Helen Dedier,Lorraine Dales,Christine Moore,Allison McGeer +10 more
TL;DR: Sinks are a potential reservoir for environment- to-patient and patient-to-patient transmission and could be a source of drinking water for hospitals and other institutions.
Journal ArticleDOI
Multiyear, Multinational Survey of the Incidence and Global Distribution of Metallo-β-Lactamase-Producing Enterobacteriaceae and Pseudomonas aeruginosa.
Krystyna M. Kazmierczak,Sharon Rabine,Meredith Hackel,Robert E. McLaughlin,Douglas J. Biedenbach,Samuel K. Bouchillon,Daniel F. Sahm,Patricia A. Bradford +7 more
TL;DR: The in vitro activities of all tested antibiotics against MBL-positive Enterobacteriaceae were significantly reduced with the exception of aztreonam-avibactam, whereas colistin was the most effective agent against M BL-positive P. aeruginosa isolates.