Journal ArticleDOI
Persistent estrogen responsiveness of ras oncogene-transformed mouse mammary epithelial cells.
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Estrogen responsiveness of T1/Pr1 cells was demonstrated by their suppression of growth in phenol red-free and/or tamoxifen-supplemented medium and by the reversal of antiproliferative effect of tamoxIFen by Phenol red and estradiol.About:
This article is published in Steroids.The article was published on 1992-06-01. It has received 37 citations till now. The article focuses on the topics: Estrogen & Oncogene.read more
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A review of mechanisms underlying anticarcinogenicity by brassica vegetables
TL;DR: The mechanisms by which brassica vegetables might decrease the risk of cancer are reviewed and animal studies carried out in humans using high but still realistic human consumption levels of indoles and Brassica vegetables have shown putative positive effects on health.
Journal ArticleDOI
Is estradiol a genotoxic mutagenic carcinogen
TL;DR: Data suggest that E2 is a weak carcinogen and weak mutagen capable of inducing genetic lesions with low frequency and may develop by hormone receptor-mediated proliferation of such damaged cells.
Journal ArticleDOI
Estrogen metabolism and breast cancer
Hamed Samavat,Mindy S. Kurzer +1 more
TL;DR: This review describes in detail estrogen metabolism and associated genetic variations, and provides a critical review of the current literature regarding the role of estrogens and their metabolites in breast cancer risk.
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Chemoprevention of Spontaneous Endometrial Cancer in Female Donryu Rats by Dietary Indole-3-carbinol
TL;DR: It is suggested that dietary I3C inhibits spontaneous occurrence of endometrial adenocarcinoma as well as preneoplastic lesions in Donryu rats and may be due to its induction of estradiol 2-hydroxylation.
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The selective estrogen enzyme modulators in breast cancer: a review.
TL;DR: Quantitative evaluation indicates that in human breast tumor E(1)S 'via sulfatase' is a much more likely precursor for E(2) than is androgens 'via aromatase, which will provide a new possibility in the treatment of this disease.
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Phenol red in tissue culture media is a weak estrogen: implications concerning the study of estrogen-responsive cells in culture
TL;DR: Phenol red has been found to have significant estrogenic activity at the concentrations (15-45 microM) at which it is found in tissue culture media as mentioned in this paper, which has been shown to stimulate the proliferation of estrogen receptor-positive MCF-7 breast cancer cells in a dose-dependent manner.
Phenol red in tissue culture media is a weak estrogen: Implications concerning the study of estrogen-responsive cells in culture (cell proliferation/human breast cancer/antiestrogens/hormone responsiveness/estrogen receptor)
TL;DR: It is found that phenol red, which bears a structural resemblance to some nonsteroidal estrogens and which is used ubiquitously as a pH indicator in tissue culture media, has significant estrogenic activity at the concentrations (15-45 microM) at which it is found in tissueculture media.
Journal Article
Inhibition of Polycyclic Aromatic Hydrocarbon-induced Neoplasia by Naturally Occurring Indoles
TL;DR: Dietary administration of all three indoles inhibited benzo(a)pyrene-induced neoplasia of the forestomach in ICR/Ha mice, and the identification of dietary constituents that can inhibit chemical carcinogens ultimately may be of value in understanding the balance of factors that determines the neoplastic response to these cancer-producing agents in the environment.
Journal Article
Proliferation, Hormonal Responsiveness, and Estrogen Receptor Content of MCF-7 Human Breast Cancer Cells Grown in the Short-Term and Long-Term Absence of Estrogens
TL;DR: There is a dissociation between the stimulation of cell proliferation and of specific protein synthesis (progesterone receptor) by estrogen under long-term estrogen-free conditions, an observation that may be relevant to understanding the growth of hormone-responsive human breast cancers in vivo.
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Effects of dietary indole-3-carbinol on estradiol metabolism and spontaneous mammary tumors in mice
TL;DR: I3C is an inducer of hepatic P450-dependent estrogen metabolism in mice, and it is chemopreventive in the C3H/OuJ mouse mammary tumor model, and this protective effect may be mediated in part by the increased 2-hydroxylation and consequent inactivation of endogenous estrogens.