Phenotyping pharyngeal pathophysiology using polysomnography in patients with obstructive sleep apnea
Scott A. Sands,Bradley A. Edwards,Bradley A. Edwards,Philip I. Terrill,Luigi Taranto-Montemurro,Ali Azarbarzin,Melania Marques,Melania Marques,L Hess,David P. White,Andrew Wellman +10 more
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TLDR
Phenotypes of pharyngeal dysfunction in OSA are evident from spontaneous changes in ventilation and ventilatory drive during sleep, enabling noninvasive phenotyping in the clinic and may facilitate precision therapeutic interventions for OSA.Abstract:
Rationale: Therapies for obstructive sleep apnea (OSA) could be administered on the basis of a patient’s own phenotypic causes (“traits”) if a clinically applicable approach were available.Objectiv...read more
Citations
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Journal ArticleDOI
Obstructive Sleep Apnea and Inflammation: Proof of Concept Based on Two Illustrative Cytokines.
TL;DR: The published links between OSAS and systemic inflammation will be critically reviewed, with special focus on the pro-inflammatory cytokines tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6), since these constitute classical prototypes of the large spectrum of inflammatory molecules that have been explored in OSAS patients.
Journal ArticleDOI
More Than the Sum of the Respiratory Events: Personalized Medicine Approaches for Obstructive Sleep Apnea
TL;DR: Treatments could be individualized based on the underlying cause of OSA; patients could better understand which symptoms and outcomes will respond to OSA treatment, and by how much; and researchers could select populations most likely to benefit from specific treatment approaches for OSA.
Journal ArticleDOI
Identifying obstructive sleep apnoea patients responsive to supplemental oxygen therapy.
Scott A. Sands,Scott A. Sands,Bradley A. Edwards,Philip I. Terrill,James P. Butler,Robert L. Owens,Robert L. Owens,Luigi Taranto-Montemurro,Ali Azarbarzin,Melania Marques,L Hess,Erik Smales,Camila Maria de Melo,David P. White,Atul Malhotra,Atul Malhotra,Andrew Wellman +16 more
TL;DR: A subgroup of patients with obstructive sleep apnoea who benefit from stabilising ventilatory control with supplemental oxygen therapy can be recognised by estimating pathophysiological mechanisms from a routine diagnostic sleep study.
Journal ArticleDOI
Sex differences in obstructive sleep apnea phenotypes, the multi-ethnic study of atherosclerosis
Christine Won,Michelle Reid,Tamar Sofer,Tamar Sofer,Ali Azarbarzin,Ali Azarbarzin,Shaun Purcell,Shaun Purcell,David P. White,David P. White,Andrew Wellman,Andrew Wellman,Scott A. Sands,Scott A. Sands,Susan Redline,Susan Redline,Susan Redline +16 more
TL;DR: There are significant sex differences in NREM-AHI levels and in physiological endotypes, and definitions that use 4%-desaturation criteria under-estimate AHI in women.
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Targeting Endotypic Traits with Medications for the Pharmacological Treatment of Obstructive Sleep Apnea. A Review of the Current Literature.
TL;DR: It is shown how recently introduced drugs for weight loss that modifyupper airway anatomy may play an important role in the management of OSA in the near future, and promising results have been obtained with drugs that increase upper airway muscle activity during sleep and reduce loop gain.
References
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Journal ArticleDOI
A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects.
TL;DR: Techniques of recording, scoring, and doubtful records are carefully considered, and Recommendations for abbreviations, types of pictorial representation, order of polygraphic tracings are suggested.
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Rules for Scoring Respiratory Events in Sleep: Update of the 2007 AASM Manual for the Scoring of Sleep and Associated Events
Richard B. Berry,Rohit Budhiraja,Daniel J. Gottlieb,David Gozal,Conrad Iber,Vishesh K. Kapur,Carole L. Marcus,Reena Mehra,Sairam Parthasarathy,Stuart F. Quan,Susan Redline,Kingman P. Strohl,Sally L. Davidson Ward,Michelle M. Tangredi +13 more
TL;DR: The task force made recommendations concerning recommended and alternative sensors for the detection of apnea and hypopnea to be used during diagnostic and positive airway pressure (PAP) titration polysomnography, and recommended scoring rules.
Journal ArticleDOI
Defining Phenotypic Causes of Obstructive Sleep Apnea. Identification of Novel Therapeutic Targets
TL;DR: It is confirmed that OSA is a heterogeneous disorder and abnormalities in nonanatomic traits are also present in most patients with OSA, and a three-point scale for weighting the relative contribution of the traits is proposed.
Journal ArticleDOI
Upper airway collapsibility in snorers and in patients with obstructive hypopnea and apnea.
Iain C. Gleadhill,Alan R. Schwartz,Norman Schubert,Robert A. Wise,Solbert Permutt,Philip L. Smith +5 more
TL;DR: Differences in upper airway collapsibility distinguish among groups of normal subjects who snore and patients with periodic hypopneas and apneas, and suggest that small differences in collapsibility along a continuum are associated with reduced airflow and altered changes in pattern of breathing.