Open AccessJournal Article
Physiology of the cerebrospinal fluid
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This article is published in La semaine des hôpitaux : organe fondé par l'Association d'enseignement médical des hôpitaux de Paris.The article was published on 1950-10-06 and is currently open access. It has received 147 citations till now.read more
Citations
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Journal ArticleDOI
Multiplicity of cerebrospinal fluid functions: New challenges in health and disease
Conrad E. Johanson,John A Duncan,Petra M. Klinge,Thomas Brinker,Edward G. Stopa,Gerald D. Silverberg +5 more
TL;DR: This review integrates eight aspects of cerebrospinal fluid (CSF) circulatory dynamics: formation rate, pressure, flow, volume, turnover rate, composition, recycling and reabsorption.
Journal ArticleDOI
Flow rate of cerebrospinal fluid (CSF) : a concept common to normal blood-CSF barrier function and to dysfunction in neurological diseases
TL;DR: A "population variation coefficient" of the CSF/serum quotients for IgG, IgA and IgM (delta Q/Q) which is evaluated as a function of increasing albumin quotients (QAlb) indicates that there was no change in blood-CSF barrier related structures with respect to diffusion controlled protein transfer from blood into CSF and hence nochange in molecular size dependent selectivity.
Journal ArticleDOI
Barrier Mechanisms in the Developing Brain
TL;DR: New evidence shows that many adult mechanisms, including functionally effective tight junctions are present in embryonic brain and some transporters are more active during development than in the adult, contributing to cerebral damage and later neurological disorders.
Journal ArticleDOI
Ion Regulation in the Brain: Implications for Pathophysiology
TL;DR: Computer simulation confirmed that elevation of [K+]o can lead to such a vicious circle and ignite seizures, spreading depression (SD), or hypoxic SD-likedepolarization (anoxic depolarization)
Journal ArticleDOI
Appearance of superoxide anion radical in cerebral extracellular space during increased prostaglandin synthesis in cats.
Hermes A. Kontos,E. P. Wei,Earl F. Ellis,L W Jenkins,John T. Povlishock,G T Rowe,Michael L. Hess +6 more
TL;DR: Results show that most of the nitroblue terrazolium reduction was accounted for by superoxide anion radical generated in the course of arachidonate metabolism via the cyclooxygenase pathway, and the most likely explanation for these findings is that increased metabolism of exogenous or endogenous archidonate via cyclo oxygengenase results in the appearance of superoxideAnion radical in cerebral extracellular space.
References
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Journal ArticleDOI
Multiplicity of cerebrospinal fluid functions: New challenges in health and disease
Conrad E. Johanson,John A Duncan,Petra M. Klinge,Thomas Brinker,Edward G. Stopa,Gerald D. Silverberg +5 more
TL;DR: This review integrates eight aspects of cerebrospinal fluid (CSF) circulatory dynamics: formation rate, pressure, flow, volume, turnover rate, composition, recycling and reabsorption.
Journal ArticleDOI
Flow rate of cerebrospinal fluid (CSF) : a concept common to normal blood-CSF barrier function and to dysfunction in neurological diseases
TL;DR: A "population variation coefficient" of the CSF/serum quotients for IgG, IgA and IgM (delta Q/Q) which is evaluated as a function of increasing albumin quotients (QAlb) indicates that there was no change in blood-CSF barrier related structures with respect to diffusion controlled protein transfer from blood into CSF and hence nochange in molecular size dependent selectivity.
Journal ArticleDOI
Barrier Mechanisms in the Developing Brain
TL;DR: New evidence shows that many adult mechanisms, including functionally effective tight junctions are present in embryonic brain and some transporters are more active during development than in the adult, contributing to cerebral damage and later neurological disorders.
Journal ArticleDOI
Ion Regulation in the Brain: Implications for Pathophysiology
TL;DR: Computer simulation confirmed that elevation of [K+]o can lead to such a vicious circle and ignite seizures, spreading depression (SD), or hypoxic SD-likedepolarization (anoxic depolarization)
Journal ArticleDOI
Appearance of superoxide anion radical in cerebral extracellular space during increased prostaglandin synthesis in cats.
Hermes A. Kontos,E. P. Wei,Earl F. Ellis,L W Jenkins,John T. Povlishock,G T Rowe,Michael L. Hess +6 more
TL;DR: Results show that most of the nitroblue terrazolium reduction was accounted for by superoxide anion radical generated in the course of arachidonate metabolism via the cyclooxygenase pathway, and the most likely explanation for these findings is that increased metabolism of exogenous or endogenous archidonate via cyclo oxygengenase results in the appearance of superoxideAnion radical in cerebral extracellular space.