Journal ArticleDOI
Placenta extract promote liver regeneration in CCl4-injured liver rat model.
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TLDR
It is suggested that hPE could be effective for liver disease through reduction of fibrosis, induction of liver regeneration, and regulation of inflammatory responses through treatment of hPE.About:
This article is published in International Immunopharmacology.The article was published on 2011-08-01. It has received 50 citations till now. The article focuses on the topics: Liver regeneration & Liver injury.read more
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Journal ArticleDOI
Down-Regulation of microRNA-26a Promotes Mouse Hepatocyte Proliferation during Liver Regeneration
TL;DR: A novel miRNA-mediated regulation pattern during the proliferative phase of LR is revealed, probably by repressing expressions of cell cycle proteins CCND2 and CCNE2.
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Placental extract protects bone marrow-derived stem/progenitor cells against radiation injury through anti-inflammatory activity
TL;DR: Interestingly, in comparison with the placebo treatment, placental extract significantly decreased the levels of the inflammatory cytokines IL-6 and TNF-α in the plasma, and this protection is likely to be related to the anti-inflammatory activity of the placental Extract.
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Anti-fatigue effects of porcine placenta and its amino acids in a behavioral test on mice
TL;DR: It is suggested that porcine placenta extract and the amino acids present in the PE should be considered a candidate anti-fatigue agent.
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Long non-coding RNA Gm2199 rescues liver injury and promotes hepatocyte proliferation through the upregulation of ERK1/2.
Qiang Gao,Yunyan Gu,Yanan Jiang,Li Fan,Zixiang Wei,Haobin Jin,Xirui Yang,Lijuan Wang,Xuguang Li,Sheng Tai,Baofeng Yang,Yan Liu +11 more
TL;DR: The ability of Gm2199 to maintain hepatic proliferation capacity indicates it as a novel anti-liver damage lncRNA.
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Effect of Mesenchymal Stem Cells and Extracts Derived from the Placenta on Trophoblast Invasion and Immune Responses
TL;DR: The effects of chorionic plate-derived mesenchymal stem cells (CP-MSCs) and human placenta extract (hPE) isolated from human normal placentas on trophoblasts invasion and immune responses are investigated.
References
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Journal ArticleDOI
Liver fibrosis – from bench to bedside
TL;DR: Current knowledge about the nature and prognosis of fibrosis in different forms of chronic liver disease with recent advances in elucidating its pathophysiology form the basis for rational treatment of hepatic fibrosis, which are summarized.
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In vitro differentiation of embryonic stem cells
TL;DR: Under appropriate conditions in culture, embryonic stem cells will differentiate and form embryoid bodies that have been shown to contain cells of the hematopoietic, endothelial, muscle and neuronal lineages, indicating that this model system provides access to early cell populations that develop in a normal fashion.
Journal ArticleDOI
Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor
Yoshihiko Uehara,Osamu Minowa,Chisato Mori,Kohei Shiota,Junko Kuno,Tetsuo Noda,Naomi Kitamura +6 more
TL;DR: In this article, the authors found that homozygous mutant embryos have severely impaired placentas with markedly reduced numbers of labyrinthine trophoblast cells, and die before birth, suggesting that HGF/SF is an essential mediator of mesenchyme-trophoblastic epithelia interaction required for placental organogenesis.
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Concise review: isolation and characterization of cells from human term placenta: outcome of the first international Workshop on Placenta Derived Stem Cells.
Ornella Parolini,Francesco Alviano,Gian Paolo Bagnara,Grozdana Bilic,Hans-Jörg Bühring,Marco Evangelista,Simone Hennerbichler,Bing Liu,Marta Magatti,Ning Mao,Toshio Miki,Fabio Marongiu,Hideaki Nakajima,Toshio Nikaido,C. Bettina Portmann-Lanz,Venkatachalam Sankar,Maddalena Soncini,Guido Stadler,Daniel Surbek,Tsuneo A. Takahashi,Heinz Redl,Norio Sakuragawa,Susanne Wolbank,Steffen M. Zeisberger,Andreas H. Zisch,Stephen C. Strom +25 more
TL;DR: The aim of this review is to summarize and provide the state of the art of research in this field, addressing aspects such as cell isolation protocols and characteristics of these cells, as well as providing preliminary indications of the possibilities for use ofThese cells in future clinical applications.
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Transplantation of bone marrow cells reduces CCl4-induced liver fibrosis in mice.
Isao Sakaida,Shuji Terai,Naoki Yamamoto,Koji Aoyama,Tsuyoshi Ishikawa,Hiroshi Nishina,Kiwamu Okita +6 more
TL;DR: Mice with BMC transplants with continuous CCl4 injection had reduced liver fibrosis and a significantly improved survival rate after BMC transplantation compared with mice treated with CCl 4 alone, and this finding introduces a new concept for the therapy of Liver fibrosis.