Journal ArticleDOI
Plasma homocyst(e)ine, folate, and vitamin B-12 concentrations and risk for early-onset coronary artery disease.
N Pancharuniti,Charles A. Lewis,Howerde E. Sauberlich,L L Perkins,Rodney C.P. Go,J O Alvarez,M Macaluso,Ronald T. Acton,R B Copeland,A L Cousins +9 more
TLDR
Reduction in plasma Hcy by interventions to increase plasma folate concentration may decrease CAD risk, and no difference in the geometric mean of vitamin B-12 concentration was found between patients and control subjects.About:
This article is published in The American Journal of Clinical Nutrition.The article was published on 1994-04-01. It has received 372 citations till now. The article focuses on the topics: Vitamin.read more
Citations
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Journal ArticleDOI
A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes
TL;DR: Higher folic acid intake by reducing tHcy levels promises to prevent arteriosclerotic vascular disease and under different assumptions, 13,500 to 50,000 CAD deaths annually could be avoided.
Journal ArticleDOI
Homocysteine and Cardiovascular Disease
TL;DR: In this article, an elevated level of total homocysteine (tHcy) in blood, denoted hyperhomocysteinemia, is emerging as a prevalent and strong risk factor for atherosclerotic vascular disease in the coronary, cerebral, and peripheral vessels, and for arterial and venous thromboembolism.
Journal ArticleDOI
Homocysteine and atherothrombosis
George N. Welch,Joseph Loscalzo +1 more
TL;DR: In 1969, McCully reported autopsy evidence of extensive arterial thrombosis and atherosclerosis in two children with elevated plasma homocyst(e)ine concentrations and homocysteine thiolactone, and it has recently become clear that hyperhomocyst (e)inemia is an independent risk factor.
Journal ArticleDOI
Homocysteine and risk of ischemic heart disease and stroke: A meta-analysis
Robert Clarke,Rory Collins,Sarah Lewington,Ann E. Donald,G. Alfthan,J. Tuomilehto,Egil Arnesen,Kaare H. Bønaa,Jacques Blacher,Godfried H.J. Boers,Andrew G. Bostom,M. L. Bots,D. E. Grobbee,Lars Brattström,Monique M.B. Breteler,A. Hofman,John C. Chambers,Jaspal S. Kooner,B. M. Coull,R. W. Evans,Lewis H. Kuller,S. Evers,Aaron R. Folsom,G. Freyburger,F. Parrot,J. Genest Jr,K. Dalery,I. M. Graham,Leslie Daly,Ellen K. Hoogeveen,Pieter J. Kostense,C.D.A. (Coen) Stehouwer,P. N. Hopkins,Paul F. Jacques,Jacob Selhub,F. C. Luft,P. Jungers,Arne Lindgren,Y. I. Lolin,F. Loehrer,Brian Fowler,Mohammad Azam Mansoor,M. R. Malinow,Pierre Ducimetière,Ottar Nygård,Helga Refsum,S. E. Vollset,Per Magne Ueland,G. S. Omenn,S. A. A. Beresford,J. M. Roseman,H. H. Parving,M. A. Gall,Ivan J. Perry,S Ebrahim,A. G. Shaper,Killian Robinson,D. W. Jacobsen,Steven M. Schwartz,David S. Siscovick,Meir J. Stampfer,C. H. Hennekens,Edith J. M. Feskens,Daan Kromhout,J. Ubbink,P. Elwood,J. Pickering,Petra Verhoef,A. Von Eckardstein,Helmut Schulte,Gerd Assmann,Nicholas J. Wald,M. R. Law,Peter H. Whincup,D. E. L. Wilcken,Paul Sherliker,P. Linksted,G Davey Smith +77 more
TL;DR: This meta-analysis of observational studies suggests that elevated homocysteine is at most a modest independent predictor of IHD and stroke risk in healthy populations.
Journal ArticleDOI
Plasma homocysteine as a risk factor for vascular disease: The European Concerted Action Project.
Graham Im,Leslie Daly,Helga Refsum,Killian Robinson,Lars Brattström,Per Magne Ueland,Roberto Palma-Reis,Godfried H.J. Boers,Richard G. Sheahan,Israelsson B,Cuno S.P.M. Uiterwaal,Raymond Meleady,Dorothy McMaster,Petra Verhoef,Jacqueline C.M. Witteman,Paolo Rubba,Bellet H,Jan C. Wautrecht,de Valk Hw,Sales Lúis Ac,Parrot-Rouland Fm,K.S. Tan,I.M. Higgins,Danielle Garcon,Generoso Andria +24 more
TL;DR: An increased plasma total homocysteine level confers an independent risk of vascular disease similar to that of smoking or hyperlipidemia, and compared with nonusers of vitamin supplements, the small number of subjects taking such vitamins appeared to have a substantially lower risk ofascular disease, a proportion of which was attributable to lower plasma homocy steine levels.
References
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Journal ArticleDOI
Estimation of the Concentration of Low-Density Lipoprotein Cholesterol in Plasma, Without Use of the Preparative Ultracentrifuge
TL;DR: A method for estimating the cholesterol content of the serum low-density lipoprotein fraction (Sf0-20) is presented and comparison of this suggested procedure with the more direct procedure, in which the ultracentrifuge is used, yielded correlation coefficients of .94 to .99.
Book
The metabolic basis of inherited disease
TL;DR: The metabolic basis of inherited disease, the metabolic basis for inherited disease as mentioned in this paper, The metabolic basis in inherited disease and inherited diseases, and inherited disease diagnosis and management, in the context of inherited diseases
Journal ArticleDOI
Hyperhomocysteinemia: an independent risk factor for vascular disease.
Robert Clarke,Leslie Daly,Killian Robinson,E. R. Naughten,Seamus F. Cahalane,Brian Fowler,Ian D. Graham +6 more
TL;DR: Hyperhomocysteinemia is an independent risk factor for vascular disease, including coronary disease, and in most instances is probably due to cystathionine beta-synthase deficiency.