Journal ArticleDOI
Plasma-noradrenaline in essential hypertension
TLDR
It is proposed that stimulation of the sympathetic nervous system by postural challenge provides a means for identifying a subgroup of younger patients with essential hypertension in whom sympathetic overactivity may play an important rule.About:
This article is published in The Lancet.The article was published on 1977-05-21. It has received 152 citations till now. The article focuses on the topics: Essential hypertension & Sympathetic nervous system.read more
Citations
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Journal ArticleDOI
Power spectral analysis of heart rate and arterial pressure variabilities as a marker of sympatho-vagal interaction in man and conscious dog.
Massimo Pagani,Federico Lombardi,Stefano Guzzetti,Ornella Rimoldi,Raffaello Furlan,Paolo Pizzinelli,Giulia Sandrone,Gabriella Malfatto,Simonetta Dell’Orto,E Piccaluga +9 more
TL;DR: The spontaneous beat-to-beat oscillation in R-R interval during control recumbent position, 90° upright tilt, controlled respiration and acute and chronic β-adrenergic receptor blockade was analyzed, indicating that sympathetic nerves to the heart are instrumental in the genesis of low-frequency oscillations in R -R interval.
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Changes in autonomic regulation induced by physical training in mild hypertension.
M. Pagani,Virend K. Somers,Raffaello Furlan,Simonetta Dell’Orto,James Conway,Giuseppe Baselli,S. Cerutti,Peter Sleight,Alberto Malliani +8 more
TL;DR: The index a is proposed as a quantitative indicator of the changes in the gain of baroreceptor mechanisms occurring with physical training in mild hypertension and during a 24-hour period in ambulatory subjects.
Journal ArticleDOI
Heart rate variability
Marek Malik,A. J. Camm +1 more
TL;DR: This chapter will review the methodology ofHRV measurement, the physiological basis of HRV and the factors influencing HRV.
Journal ArticleDOI
Plasma catecholamines and essential hypertension. An analytical review.
TL;DR: The preponderance of literature on the subject supports the hypothesis that increased plasma catecholamine concentrations occur in some patients with essential hypertension, and is consistent with a pathophysiologic role for increased sympathetic neural activity in this subgroup of hypertensive patients.
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Reduced β-adrenoceptor sensitivity in the elderly
TL;DR: It was found that the effectiveness of any given free concentration diminished progressively with age, consistent with a diminished responsiveness of the β‐adrenoceptor to both agonist and antagonist drugs with advancing years.
References
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Use of plasma norepinephrine for evaluation of sympathetic neuronal function in man.
TL;DR: Levels of norepinephrine in human plasma have been determined by a radioenzymatic technique sufficiently sensitive to measure 0.014 ng NE per ml plasma by evaluating sympathetic neuronal function based on the increments in plasma NE produced by postural change and a standard amount of exertion.
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Mild high-renin essential hypertension. Neurogenic human hypertension?
Murray D. Esler,Stevo Julius,Andrew J. Zweifler,Otelio S. Randall,Ernest Harburg,Hermsworth Gardiner,Vincent DeQuattro +6 more
TL;DR: Patients with high-renin hypertension, but not those with normal plasma renin activity, exhibited suppressed hostility, a behavioral pattern linked to increased sympathetic activity, which is neurogenic and possibly psychosomatic in origin.
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A sensitive radioenzymatic assay for norepinephrine in tissues and plasma
TL;DR: A procedure for measuring picogram quantities of norepinephrine has been developed utilizing partially purified bovine adrenal phenylethanolamine-N-methyl-transferase and 3 [H]-S-adenosyl-methionine, applicable to many body tissues and fluids, including brain and plasma.
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Circulating catecholamine levels in human and experimental hypertension.
TL;DR: The findings suggest that the sympathetic system may play an important role in maintaining an elevated blood pressure in experimental hypertension and in a significant proportion of patients with essential hypertension.
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Age-Adjusted Plasma Norepinephrine Levels Are Similar in Normotensive and Hypertensive Subjects
TL;DR: The sympathetic nervous system has been implicated in the pathogenesis of hypertension because of its role in controlling blood pressure and because many drugs that have been found useful in the system are unknown.