Journal ArticleDOI
Plasmid-Borne Multiple Drug Resistance in Vibrio cholerae Serogroup O1, Biotype El Tor: Evidence for a Point-Source Outbreak in Bangladesh
Roger I. Glass,M. I. Huq,John V. Lee,E. J. Threlfall,M. R. Khan,Abdul Alim,Bernard Rowe,R. J. Gross +7 more
TLDR
In 1979, an outbreak of plasmid-borne, multiply drug-resistant Vibrio cholerae serogroup O1 biotype El Tor occurred in the Matlab area of Bangladesh, and C plasmids detected in the nonvibrio flora of family contacts probably came from the resistant strain of V. cholera O1.Abstract:
In 1979, an outbreak of plasmid-borne, multiply drug-resistant Vibrio cholerae serogroup O1 biotype El Tor (V. cholerae O1) occurred in the Matlab area of Bangladesh. The outbreak could have resulted from the introduction into the area of a single resistant strain or from multiple conjugations of drug-sensitive V. cholerae O1 with C plasmids in other environmental flora. Resistant strains were phage typed to determine their relatedness, and plasmid studies were conducted to determine the frequency of C plasmids in nonvibrio flora of family contacts of cholera patients. Forty-one (85%) of 48 resistant strains of V. cholerae O1 examined belonged to two closely related phage types new to the area, whereas 59 drug-sensitive strains from the same period were primarily of two different phage types. Group C plasmids were in nonvibrio strains from five of 36 family contacts of patients with drug-resistant cholera but none of 82 family contacts of patients with sensitive cholera. This outbreak most likely began from the introduction into the area of a single, multiply drug-resistant strain of V. cholerae O1. C plasmids detected in the nonvibrio flora of family contacts probably came from the resistant strain of V. cholerae O1.read more
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Epidemiology, Genetics, and Ecology of Toxigenic Vibrio cholerae
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Molecular analysis of antibiotic resistance gene clusters in vibrio cholerae O139 and O1 SXT constins.
TL;DR: It is indicated that there is considerable flux in the antibiotic resistance genes found in the SXT family of constins and point to a model for the evolution of these related mobile elements.
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Antibiotic resistance mechanisms of Vibrio cholerae.
TL;DR: In this article, the initial identification and subsequent evolution of antibiotic-resistant strains of Vibrio cholerae are discussed. But, the authors do not discuss the evolution of these strains.