Plasmodium falciparum and intestinal parasitic co-infections in HIV-infected patients in Benin City, Edo State, Nigeria
TLDR
Evidence of co-infections between Plasmodium falciparum and intestinal parasites in HIV and intestinal parasitic infections is provided as this will enhance better management of HIV-infected patients.Abstract:
Introduction: Human co-infection with Plasmodium falciparum and helminthes is ubiquitous throughout Africa. This study aimed to determine the co-infections of Plasmodium falciparum infection in HIV and intestinal parasitic infections, and their immunological distribution, in Benin City, Nigeria. Methodology: A total of 2,000 stool specimens from HIV-positive patients and 500 controls (HIV-negative individuals) were examined for ova, cysts, or parasites using standard procedures. In addition, patients' blood samples were analyzed for CD4 counts by flow cytometry and examined for Plasmodium falciparum by microscopy. Results: The prevalence of single parasitic infection among HIV patients was 18.1% in males and 16.9% among females with no significant difference (p = 0.536) while gender was a risk factor in multiple parasitic infections (male versus female: 4.2% and 1.8% OR = 2.384; 95% CI = 1.371, 4.147) (p = 0.0025). Increasing age was not associated with increased risk of both single and multiple parasitic infections (p = 0.083; p = 0.248). CD4 + T cell count less than 200 cells/µl was a risk factor for acquiring single and multiple parasitic infections among HIV patients (OR = 5.565; 95% CI = 4.136, 7.486; p = 0.0001; OR = 4.283; 95% CI = 2.424, 7.566; p = 0.0001). The most common co-infection observed was between Plasmodium falciparum and Ascaris lumbricoides 43% (10) among HIV patients. Conclusion: This study provides evidence of co-infections between Plasmodium falciparum and intestinal parasites. Diagnosis of parasitic infections among HIV patients is advocated as this will enhance better management of HIV-infected patients.read more
Citations
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Frequency of opportunistic and other intestinal parasitic infections in patients infected with human immunodeficiency virus in Bangladesh
Rashed Noor,Shekhar Ranjan Saha,Farjana Rahman,Saurab Kishore Munshi,Md. Aftab Uddin,M Majibur Rahman +5 more
TL;DR: Cryptosporidium prevailed in HIV-positive patients with diarrhea, and interestingly, polyparasitic infections were demonstrated in chronic cases with a low CD4 count, therefore, regular antienteric parasitic prophylactic trials are recommended in for patients with lowCD4 cell count.
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Co-Endemicity of Plasmodium falciparum and HIV-Infections in Treated Patients is Uncorrelated in Benin City, Nigeria
Frederick,Olusegun Akinbo,Richard Omoregie,Luke Dixon,Kyle Brown,Richard J. A. Wilson,Mastanna Eraifej,Sabrina Peoples,Adam Curtis,Skyler Battle,Dymekea Bellamy,Lea Shyneque,Rocetia Robinson,D. C. Ghislaine Mayer,Johanna M Porter-Kelley +14 more
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Intestinal parasitic infections among artisans in Benin city, Nigeria
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Intestinal Parasitosis among HIV Positive Patients Accessing Healthcare in a Medical Centre in Norhtern Nigeria
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References
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Journal ArticleDOI
Correlation between CD4 counts of HIV patients and enteric protozoan in different seasons – An experience of a tertiary care hospital in Varanasi (India)
TL;DR: There was an inverse relation between the CD4 counts and duration of diarrhea and the maximum parasitic isolation was in the patients whose CD4 cell counts were below 200 cells/μl.
Journal Article
Prevalence of intestinal parasitic infestation in HIV/AIDS patients with diarrhea in Madurai City, South India.
Kuppamuthu Ramakrishnan,R. Shenbagarathai,Alagappan Uma,Karuppusamy Kavitha,R. Rajendran,Ponniah Thirumalaikolundusubramanian +5 more
TL;DR: It is suggested that enteric infections are more common in HIV/infected patients than in HIV-negative persons in south India, and this may be due to differences in immunological profile, susceptibility as well as factors related to sanitation and the environment.
Journal ArticleDOI
Soil Chemistries Define Aquatic Habitats with Immature Populations of the Culicoides variipennis Complex (Diptera: Ceratopogonidae)
TL;DR: Level of salt-forming ions and indicators of salinity, notably sodium, chloride, magnesium, sulfate, boron, and conductivity, were elevated in substrates supporting all 3 species, with values that declined from very high to high across the arid west to moderate east of the Mississippi river, and differed significantly among species.
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Contemporaneous and successive mixed Plasmodium falciparum and Plasmodium vivax infections are associated with Ascaris lumbricoides: an immunomodulating effect?
Mathieu Nacher,Pratap Singhasivanon,U. Silachomroon,Weerapong Phumratanaprapin,Sornchai Looareesuwan +4 more
TL;DR: It is suggested the possibility that pre-existing Ascaris infection may increase tolerance of the host to different Plasmodium spp.
Age and Sex Distribution of Intestinal Parasitic Infection Among HIV Infected Subjects in Abeokuta, Nigeria
Marcellinus Okodua,Oluwaseyi Adeyeba Adegboyega,Youtchou Tatfeng Mirabeau,Herbert Okpala Obi +3 more
TL;DR: Adequate treatment, proper health education and good hygiene will help in reducing intestinal parasitic infection.