Platelet-derived growth factor stimulates activity of low density lipoprotein receptors
TLDR
It is suggested that the platelet-derived growth factor can increase both the exogenous and endogenous supplies of cholesterol to the cell for its use during cell proliferation.Abstract:
Partially purified platelet-derived growth factor stimulates low density lipoprotein binding and degradation in cultured aortic smooth muscle cells of monkeys by increasing the number of available low density lipoprotein receptors. When platelet-derived growth factor was added to quiescent cells, low density lipoprotein binding increased within 4-8 hr. Stimulation of low density lipoprotein receptor activity preceded stimulation of DNA synthesis by platelet-derived growth factor by 8-12 hr. Enhancement of endogenous cholesterol synthesis by platelet-derived growth factor preceded stimulation of low density lipoprotein receptor activity. These findings suggest that the platelet-derived growth factor can increase both the exogenous and endogenous supplies of cholesterol to the cell for its use during cell proliferation.read more
Citations
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Journal ArticleDOI
The Pathogenesis of Atherosclerosis — An Update
TL;DR: A response-to-injury hypothesis of atherogenesis proposes that "injury" to the endothelium is the initiating event in atherosclerosis, and intimal smooth-muscle proliferation as the key event in the development of the advanced lesions of Atherosclerosis.
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Regulation of plasma cholesterol by lipoprotein receptors
TL;DR: The lipoprotein transport system holds the key to understanding the mechanisms by which genes, diet, and hormones interact to regulate the plasma cholesterol level in man.
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Replication of smooth muscle cells in vascular disease.
TL;DR: This review attempts to consider the current state of knowledge of the mechanisms controlling smooth muscle proliferation in these two diseases, to put that knowledge into the context of what is known about smooth muscle biology, and to offer two hypotheses on the possible roles of smooth muscle developmental biology in manifestations of atherosclerosis and hypertension in adult humans.
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Studies of hypercholesterolemia in the nonhuman primate. II. Fatty streak conversion to fibrous plaque.
A Faggiotto,R Ross +1 more
TL;DR: The results of these studies helped to understand the complicated interrelationships between the various cells in atherogenesis, provided further support for the “Response to Injury Hypothesis of Atherosclerosis” and helped to explain how hypercholesterolemia may be involved in the different stages of Atherogenesis in nonhuman primates and possibly in humans.
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George Lyman Duff Memorial Lecture. Atherosclerosis: a problem of the biology of arterial wall cells and their interactions with blood components.
TL;DR: In this lecture, a series of questions concerning the role played by each of the cells of the blood and of the artery wall as well as the role of cholesterol in atherosclerosis are raised.
References
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