Journal ArticleDOI
Platelet glutathione peroxidase activity as an index of selenium status in rats.
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TLDR
Determination of glutathione peroxidase activity in platelets apparently is a promising technique for assessing selenium status and, possibly, for measuring selenum bioavailability.Abstract:
Glutathione peroxidase activity in platelets increased stepwise in selenium-depleted rats that were repleted with graded levels of dietary sodium selenite. In a 3-phase depletion/repletion/depletion feeding study, glutathione peroxidase activity was similar in platelets and liver, which apparently contains the largest labile pool of selenium in the body. The activity of glutathione S-transferase (selenium-independent glutathione peroxidase) in platelets was low and was not affected by selenium deficiency, even though hepatic transferase was markedly elevated in selenium-deficient rats. Vitamin E deficiency did not affect activities of glutathione peroxidase or glutathione S-transferase in platelets or liver. Determination of glutathione peroxidase activity in platelets apparently is a promising technique for assessing selenium status and, possibly, for measuring selenium bioavailability.read more
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Biochemical responses in aquatic animals: A review of determinants of oxidative stress
Richard T. Di Giulio,Peter C. Washburn,Richard J. Wenning,Gary W. Winston,Catherine S.E. Jewell +4 more
TL;DR: In this paper, an approach only recently investigated by aquatic toxicologists will be described and reviewed in detail, based on theories of oxyradical generation and subsequent oxidative stress in biological systems.
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Arsenic, selenium, boron, lead, cadmium, copper, and zinc in naturally contaminated rocks: A review of their sources, modes of enrichment, mechanisms of release, and mitigation strategies.
Carlito Baltazar Tabelin,Toshifumi Igarashi,Mylah Villacorte-Tabelin,Ilhwan Park,Einstine M. Opiso,Mayumi Ito,Naoki Hiroyoshi +6 more
TL;DR: This review summarized all available studies in the literature about the factors and processes crucial in the enrichment, release, and migration of the most commonly encountered hazardous and toxic elements in naturally contaminated geological materials to focus on naturally contaminated rocks.
Journal ArticleDOI
Selenium metabolism and bioavailability.
TL;DR: The bioavailability, including absorption, transport, metabolism, storage, and excretion, of the different forms of exogenous and endogenous Se are reviewed.
Journal ArticleDOI
Effects of nationwide addition of selenium to fertilizers on foods, and animal and human health in Finland: From deficiency to optimal selenium status of the population
Georg Alfthan,Merja Eurola,Päivi Ekholm,Eija-Riitta Venäläinen,Tarja Root,Katja Korkalainen,Helinä Hartikainen,Pirjo Salminen,Veli Hietaniemi,Pentti Aspila,Antti Aro +10 more
TL;DR: In the Nordic countries of Finland, the average dietary human intake increased from 0.04 mg Se/day/10 MJ in 1985 to a present plateau of 1.40 μmol/L that can be considered to be an optimal status.
Journal ArticleDOI
Bioavailability of selenium to Finnish men as assessed by platelet glutathione peroxidase activity and other blood parameters.
O A Levander,Georg Alfthan,H Arvilommi,C G Gref,Jussi K. Huttunen,M Kataja,Pekka Koivistoinen,J Pikkarainen +7 more
TL;DR: Three groups of 10 men of low selenium status were given 200 micrograms Se/day as Serich wheat, Se-rich yeast, or sodium selenate for 11 wk to determine the covertibility of tissue Se stores to biologically active Se and platelet GSH-Px was higher in the wheat and yeast groups than in the selenates.