Journal ArticleDOI
Polarographic Oxidation of Diaminopyrimidines
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TLDR
The effects of varying concentrations, temperature, pH, buffer concentration, rate of rotation of electrode and rate of scanning of potential were determined in the polarographic oxidation of polyamino-and aminohydroxy-pyrimidines as mentioned in this paper.Abstract:
The polarographic oxidation of 2, 5-diaminopyrimidine (IV) and 4,5-diaminopyrimidine (V) at the rotating Pt microelectrode in aqueous buffered solutions was studied. The effects of varying concentrations, temperature, pH, buffer concentration, rate of rotation of electrode and rate of scanning of potential were determined. The limiting currents are diffusion controlled and proportional to concentration up to 1 × 10−3 M for (IV) and 2 × 10−4 M for (V). The overall reaction is irreversible and probably involves two electrons per molecule to give an unstable product with a quinonimine structure. The dependence of E½ on pH in the anodic polarography of twelve more polyamino- and aminohydroxy-pyrimidines was determined. Huckel type MO calculations were carried out for the pyrimidines and the energies calculated for the highest occupied MOs were correlated with E°½ values.read more
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Book ChapterDOI
Electrolysis of N-Heterocyclic Compounds
TL;DR: In this article, the electrolysis of N-heterocyclic compounds is discussed and the polarographic results are provided to supplement the discussion and to suggest further use of preparative electrolysis.
Journal ArticleDOI
Electrochemical behavior of 3-amino-pyridine, 2,3-diamino-pyridine and 2,6-diamino-pyridine in aqueous solutions
TL;DR: In this article, the electrochemical behavior of 3-amino-pyridine, 2,3-diamino pyridine and 2,6diaminopyridine has been investigated in the pH range 0.7-13 at platinum and carbon paste solid electrodes with periodical renewal of the diffusion layer.
Book ChapterDOI
Polarography and voltammetry of nucleosides and nucleotides and their parent bases as an analytical and investigative tool.
Journal ArticleDOI
Investigation of antimalarial drug pyrimethamine and its interaction with dsDNA by electrochemical and spectroscopic techniques
TL;DR: In this article, the electrochemical behavior of the antimalarial drug pyrimethamine (PMT) was examined at a screen printed carbon electrode (SPCE) in different aqueous supporting electrolytes using cyclic voltammetry (CV) and differential pulse voltammetric (DPV).
Journal ArticleDOI
Mechanism of electrochemical oxidation of trimethoprim at pyrolytic graphite electrode
Rekha Goyal,Anoop Kumar +1 more
TL;DR: In this paper, the electrochemical oxidation behavior of trimethoprim was investigated at a pyrolytic graphite electrode over a wide pH range (1.35-10.71).
References
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Journal ArticleDOI
Studies on the Structure of the Primary Oxidation Product Formed from Tetrahydropteridines during Phenylalanine Hydroxylation
Journal ArticleDOI
Purine studies. Part II. The ultra-violet absorption spectra of some mono- and poly-substituted purines
Journal ArticleDOI
A Proposed Structure for Folinic Acid-SF, a Growth Factor Derived from Pteroylglutamic Acid
Journal ArticleDOI
The nature of the primary oxidation product formed from tetrahydropteridines during phenylalanine hydroxylation.
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