Postoperative analgesia with controlled-release morphine sulphate: comparison with intramuscular morphine.
Reads0
Chats0
TLDR
Morphine sulphate tablets produced satisfactory postoperative analgesia compared with intramuscular morphine: both regimens were acceptable to the patients.Abstract:
Fifty patients undergoing hysterectomy or cholecystectomy took part in a trail of postoperative analgesia provided by either intramuscular morphine or controlled-release morphine sulphate tablets orally. Respiratory function and plasma catecholamine concentrations were measured after operation and pain was assessed by using a linear analogue scoring method. Controlled-release morphine sulphate produced comparable pain relief with that of intramuscular morphine, and depression of respiratory function after operation was similar with the two analgesic regimens. The mean total dose of drug per patient given over 48 h to patients undergoing hysterectomy was 115 mg for morphine sulphate and 53 mg for morphine. Patients undergoing cholecystectomy received 130 mg morphine sulphate or 76 mg morphine. There was more sedation after operation in those patients undergoing hysterectomy who received morphine sulphate tablets. Morphine sulphate tablets produced satisfactory postoperative analgesia compared with intramuscular morphine: both regimens were acceptable to the patients.read more
Citations
More filters
Journal ArticleDOI
Policy for controlling pain after surgery: effect of sequential changes in management.
T. H. Gould,D. L. Crosby,M. Harmer,S. M. Lloyd,J. N. Lunn,G. A. D. Rees,D. E. Roberts,Joan Webster +7 more
TL;DR: The introduction of an acute pain service to the general surgical wards of a large teaching hospital led to considerable improvement in the level of postoperative pain as assessed by visual analogue scores.
Journal ArticleDOI
Sympathoadrenal responses to anaesthesia and surgery
TL;DR: Measurements of heart rate, arterial pressure and skin resistance have been used as indirect indices of the level of sympathetic activity to assess both the efficacy of premedication and depth of anaesthesia.
Journal ArticleDOI
The relief of pain in laboratory animals.
TL;DR: The most generally useful agent at present seems to be buprenorphine which can be used to provide effective, long lasting analgesia in a wide range of species.
Journal ArticleDOI
Pain, sedation and reaction time during long-term treatment of cancer patients with oral and epidural opioids
Per Sjøgren,Anne-Marie Banning +1 more
TL;DR: No differences were found between CRT values and VAS scores in cancer patients treated with chronic oral opioids versus epidural opioids, therefore at this dose level of chronic opioid treatment, the advantage of epidural administration seems questionable.
Journal ArticleDOI
A comparison of midazolam and diazepam for intravenous sedation in dentistry
TL;DR: In a randomised cross‐over trial, midazolam, a new water soluble benzodiazepine was compared with the conventional diazepam preparation (Valium) in 34 patients aged 16—45 years who were undergoing outpatient conservation dentistry and showed advantages in providing a faster onset of action, higher incidence of amnesia and more rapid recovery.
References
More filters
Journal ArticleDOI
The reliability of a linear analogue for evaluating pain.
TL;DR: A linear analogue for rating pain with 10, 15 and 20 cm lines is significantly less variable than a 5 cm line and the linear analogue rating of a constant pain stimulus is reproducible and changes in rating are likely to be real changes of opinion.
Journal ArticleDOI
Epidural narcotics for postoperative analgesia.
TL;DR: It is concluded that epidural narcotics in adequate dosage are an effective means for production of prolonged and segmental postoperative analgesia.
Journal ArticleDOI
The relationship of pharmacokinetics to pharmacological activity: morphine, methadone and naloxone.
TL;DR: Based on urinary excretion data in man, accelerated morphine metabolism and excretion do not contribute to morphine tolerance and the rapid onset of the narcotic antagonist action of naloxone can be related to its rapid entry into the brain, whereas its potency stems in part from its high lipid solubility which allows a high brain concentration.
Journal ArticleDOI
Plasma Catecholamine and Cortisol Responses to Fentanyl–Oxygen Anesthesia for Coronary-artery Operations
Journal ArticleDOI
The disposition of morphine in surgical patients
TL;DR: The studies demonstrate the applicability and specificity of the radioimmunoassay for morphine and suggest that serum levels of morphine may be a useful and objective indicator of its pharmacologic activity.