Journal ArticleDOI
Prediagnostic serum selenium and risk of cancer.
Walter C. Willett,J. Steven Morris,Sara L. Pressel,James Taylor,B. Frank Polk,Meir J. Stampfer,Bernard Rosner,Kenneth. Schneider,Curtis G. Hames +8 more
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TLDR
The association between low selenium level and cancer was strongest for gastrointestinal and prostatic cancers and Serum levels of vitamins A and E compounded the effect of low Selenium.About:
This article is published in The Lancet.The article was published on 1983-07-16. It has received 539 citations till now. The article focuses on the topics: Selenium & Selenium deficiency.read more
Citations
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Journal ArticleDOI
Dietary carcinogens and anticarcinogens Oxygen radicals and degenerative diseases
TL;DR: Dietary intake of natural antioxidants could be an important aspect of the body's defense mechanism against these agents of cancer and other age-related diseases.
Journal ArticleDOI
Effects of Selenium Supplementation for Cancer Prevention in Patients With Carcinoma of the Skin: A Randomized Controlled Trial
Larry C. Clark,Gerald F. Combs,Bruce W. Turnbull,Elizabeth H. Slate,Dan K. Chalker,James Chow,Loretta S. Davis,Renee A. Glover,Gloria F. Graham,Earl G. Gross,Arnon Krongrad,Jack L. Lesher,H. Kim Park,Beverly B. Sanders,Cameron L. Smith,J. Richard Taylor +15 more
TL;DR: Results from secondary end-point analyses support the hypothesis that supplemental selenium may reduce the incidence of, and mortality from, carcinomas of several sites and require confirmation in an independent trial of appropriate design before new public health recommendations regarding seenium supplementation can be made.
Journal ArticleDOI
Selenium in human health and disease.
Susan J. Fairweather-Tait,Yongping Bao,Martin R. Broadley,Rachel Collings,Dianne Ford,John E. Hesketh,Rachel Hurst +6 more
TL;DR: The relationships between selenium intake/status and health, or risk of disease, are complex but require elucidation to inform clinical practice, to refine dietary recommendations, and to develop effective public health policies.
Journal ArticleDOI
Selenium in cancer prevention: a review of the evidence and mechanism of action
TL;DR: Current primary and secondary prevention trials of Se are underway in the USA, including the Selenium and Vitamin E Cancer Prevention Trial (SELECT) relating to prostate cancer, although a large European trial is still desirable given the likelihood of a stronger effect in populations of lower Se status.
Journal ArticleDOI
Chemopreventive agents: selenium.
Gerald F. Combs,William P. Gray +1 more
TL;DR: According to this two-stage model of the roles of Se in cancer prevention, individuals with nutritionally adequate Se intakes may benefit from Se supplementation and the development of the potential of Se compounds as cancer chemopreventive agents is facilitated.
References
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Simultaneous determination of alpha-tocopherol and retinol in plasma or red cells by high pressure liquid chromatography.
TL;DR: Compared with conventional methods for these vitamins, the rapid, microprocedure for the simultaneous determination of alpha-tocopherol and retinol in plasma and alone in red cells gave excellent agreement with conventional Methods.
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A Stable Reagent for the Liebermann-Burchard Reaction. Application to Rapid Serum Cholesterol Determination
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Cancer mortality correlation studies-III: Statistical associations with dietary selenium intakes
TL;DR: The results support the hypothesis that selenium has cancer-protecting effects in man and a change of diet aimed at increasing the dietary selenum supply is suggested as a possible means of lowering the human cancer risk.
Book
Surveillance, epidemiology, and end results : incidence and mortality data, 1973-1977
TL;DR: This monograph reports detailed information on the incidence of and mortality from cancer in the United States during the initial five years of the National Cancer Institutes Surveillance Program 1973-1977.
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Antioxidants and cancer. Part VI. Selenium and age-adjusted human cancer mortality.
TL;DR: In the states with high selenium levels, there was significantly lower mortality in both males and females from several types of cancer, particularly the environmental problem indicators, such as gastrointestinal and urogenital types ofcancer.